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The degradation of L-lysine in guinea pig liver homogenate: formation of alpha-aminoadipic acid

Borsook, Henry and Deasy, Clara L. and Haagen-Smit, A. J. and Keighley, Geoffrey and Lowy, Peter H. (1948) The degradation of L-lysine in guinea pig liver homogenate: formation of alpha-aminoadipic acid. Journal of Biological Chemistry, 176 (3). pp. 1383-1393. ISSN 0021-9258.

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A summary of the little that is known of the metabolism of lysine in animals is as follows: it is indispensable in the diet, its α-amino group does not participate in reversible transamination reaction in vivo (2), neither the L nor D form is attacked by the appropriate amino acid oxidase, certain ε-nitrogen-substituted derivatives can replace lysine in the diet and their α-amino groups are oxidized by amino acid oxidases (3, 4), no α-nitrogen-substituted derivatives yet prepared can substitute for lysine in the diet (4-6).

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Additional Information:© 1948 American Society of Biological Chemists. Received for publication, June 21, 1948. The authors were assisted by A. A. Dvorsky, D. Eggarter, H. E. Jeffery, G. Oppenheimer, and A. Tollestrup. This work is a part of that done under contract with the Office of Naval Research, United States Navy Department. A summary of this work has been reported (1). The C14 used in this investigation was supplied by the Monsanto Chemical Company, Clinton Laboratories, Oak Ridge, Tennessee, and obtained on allocation from the United States Atomic Energy Commission.
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Office of Naval ResearchUNSPECIFIED
Atomic Energy CommissionUNSPECIFIED
Issue or Number:3
Record Number:CaltechAUTHORS:BORjbc48c
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:11807
Deposited By: Tony Diaz
Deposited On:03 Oct 2008 18:56
Last Modified:03 Oct 2019 00:22

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