CaltechAUTHORS
  A Caltech Library Service

The degradation of L-lysine in guinea pig liver homogenate: formation of alpha-aminoadipic acid

Borsook, Henry and Deasy, Clara L. and Haagen-Smit, A. J. and Keighley, Geoffrey and Lowy, Peter H. (1948) The degradation of L-lysine in guinea pig liver homogenate: formation of alpha-aminoadipic acid. Journal of Biological Chemistry, 176 (3). pp. 1383-1393. ISSN 0021-9258. https://resolver.caltech.edu/CaltechAUTHORS:BORjbc48c

[img]
Preview
PDF - Published Version
See Usage Policy.

766kB

Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:BORjbc48c

Abstract

A summary of the little that is known of the metabolism of lysine in animals is as follows: it is indispensable in the diet, its α-amino group does not participate in reversible transamination reaction in vivo (2), neither the L nor D form is attacked by the appropriate amino acid oxidase, certain ε-nitrogen-substituted derivatives can replace lysine in the diet and their α-amino groups are oxidized by amino acid oxidases (3, 4), no α-nitrogen-substituted derivatives yet prepared can substitute for lysine in the diet (4-6).


Item Type:Article
Related URLs:
URLURL TypeDescription
http://www.jbc.org/content/vol176/issue3/index.shtmlPublisherUNSPECIFIED
Additional Information:© 1948 American Society of Biological Chemists. Received for publication, June 21, 1948. The authors were assisted by A. A. Dvorsky, D. Eggarter, H. E. Jeffery, G. Oppenheimer, and A. Tollestrup. This work is a part of that done under contract with the Office of Naval Research, United States Navy Department. A summary of this work has been reported (1). The C14 used in this investigation was supplied by the Monsanto Chemical Company, Clinton Laboratories, Oak Ridge, Tennessee, and obtained on allocation from the United States Atomic Energy Commission.
Funders:
Funding AgencyGrant Number
Office of Naval ResearchUNSPECIFIED
Atomic Energy CommissionUNSPECIFIED
Issue or Number:3
Record Number:CaltechAUTHORS:BORjbc48c
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:BORjbc48c
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:11807
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:03 Oct 2008 18:56
Last Modified:03 Oct 2019 00:22

Repository Staff Only: item control page