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A peptide fraction in liver

Borsook, Henry and Deasy, Clara L. and Haagen-Smit, A. J. and Keighley, Geoffrey and Lowy, Peter H. (1949) A peptide fraction in liver. Journal of Biological Chemistry, 179 (2). pp. 705-719. ISSN 0021-9258.

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We reported in a preliminary communication (1) the isolation of a peptide fraction from guinea pig liver. The following points of interest appeared at once: many different amino acids were obtained on hydrolysis; the peptide fraction contained most of the indispensable amino acids, which indicated that it probably is important in protein metabolism; when guinea pig liver homogenate was incubated with C14-labeled glycine, leucine, or lysine, these were rapidly incorporated into this peptide fraction, which is further evidence that it is metabolically active; the peptide fraction had not been described hitherto; a fraction containing one or more large peptides can be separated from so complex a mixture as liver homogenate by starch chromatography.

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Additional Information:© 1949 American Society of Biological Chemists. Received for publication, December 29, 1948. This work is a part of that done under contract with and joint sponsorship of the Office of Naval Research, United States Navy Department, and the United States Atomic Energy Commission. The C14 used in this investigation to label amino acids was supplied by the Monsanto Chemical Company, Clinton Laboratories, Oak Ridge, Tennessee, and obtained on allocation from the United States Atomic Energy Commission.
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Office of Naval ResearchUNSPECIFIED
Atomic Energy CommissionUNSPECIFIED
Issue or Number:2
Record Number:CaltechAUTHORS:BORjbc49b
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:11811
Deposited By: Tony Diaz
Deposited On:03 Oct 2008 18:32
Last Modified:03 Oct 2019 00:22

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