Narasimhan, Vinayak and Siddique, Radwanul Hasan and Kim, Un Jeong and Lee, Suyeon and Kim, Hyochul and Roh, YoungGeun and Wang, Yibing Michelle and Choo, Hyuck (2022) Glasswing-Butterfly-Inspired Multifunctional Scleral Lens and Smartphone Raman Spectrometer for Point-of-Care Tear Biomarker Analysis. Advanced Science . Art. No. 2205113. ISSN 2198-3844. doi:10.1002/advs.202205113. (In Press) https://resolver.caltech.edu/CaltechAUTHORS:20221219-418113000.43
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Abstract
Augmenting contact lenses with sensing capabilities requires incorporating multiple functionalities within a diminutive device. Inspired by multifunctional biophotonic nanostructures of glasswing butterflies, a nanostructured scleral lens with enhanced optical, bactericidal, and sensing capabilities is reported. When used in conjunction with a smartphone-integrated Raman spectrometer, the feasibility of point-of-care applications is demonstrated. The bioinspired nanostructures made on parylene films are mounted on the anterior and posterior side of a scleral lens to create a nanostructured lens. Compared to unstructured parylene, nanostructured parylene minimizes glare by 4.3-fold at large viewing angles up to 80o. When mounted on a scleral lens, the nanostructures block 2.8-fold more ultraviolet (UVA) light while offering 1.1-fold improved transmission in the visible regime. Furthermore, the nanostructures exhibit potent bactericidal activity against Escherichia coli, killing 89% of tested bacteria within 4 h. The same nanostructures, when gold-coated, are used to perform rapid label-free multiplex detection of lysozyme and lactoferrin, the protein biomarkers of the chronic dry eye disease, in whole human tears using drop-coating deposition Raman spectroscopy. The detection of both proteins in whole human tear samples from different subjects using the nanostructured lens produced excellent correlation with commercial enzyme-based assays while simultaneously displaying a 1.5-fold lower standard deviation.
Item Type: | Article | ||||||||
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Additional Information: | V.N. and R.H.S. contributed equally to this work. This research was partially supported by the Samsung Global Research Outreach (GRO) program . The authors are also thankful for the support and resources provided by the Kavli Nanoscience Institute and the Beckman Institute Biological Imaging Facility at Caltech. | ||||||||
Group: | Kavli Nanoscience Institute | ||||||||
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DOI: | 10.1002/advs.202205113 | ||||||||
Record Number: | CaltechAUTHORS:20221219-418113000.43 | ||||||||
Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20221219-418113000.43 | ||||||||
Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||
ID Code: | 118512 | ||||||||
Collection: | CaltechAUTHORS | ||||||||
Deposited By: | Research Services Depository | ||||||||
Deposited On: | 20 Jan 2023 21:13 | ||||||||
Last Modified: | 20 Jan 2023 21:13 |
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