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A multidisciplinary Prematurity Research Cohort Study

Stout, Molly J. and Chubiz, Jessica and Raghuraman, Nandini and Zhao, Peinan and Tuuli, Methodius G. and Wang, Lihong V. and Cahill, Alison G. and Cuculich, Phillip S. and Wang, Yong and Jungheim, Emily S. and Herzog, Erik D. and Fay, Justin and Schwartz, Alan L. and Macones, George A. and England, Sarah K. (2022) A multidisciplinary Prematurity Research Cohort Study. PLoS ONE, 17 (8). Art. No. e0272155. ISSN 1932-6203. doi:10.1371/journal.pone.0272155.

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Background: Worldwide, 10% of babies are born preterm, defined as a live birth before 37 weeks of gestation. Preterm birth is the leading cause of neonatal death, and survivors face lifelong risks of adverse outcomes. New approaches with large sample sizes are needed to identify strategies to predict and prevent preterm birth. The primary aims of the Washington University Prematurity Research Cohort Study were to conduct three prospective projects addressing possible causes of preterm birth and provide data and samples for future research. Study design: Pregnant patients were recruited into the cohort between January 2017 and January 2020. Consenting patients were enrolled into the study before 20 weeks’ gestation and followed through delivery. Participants completed demographic and lifestyle surveys; provided maternal blood, placenta samples, and cord blood; and participated in up to three projects focused on underlying physiology of preterm birth: cervical imaging (Project 1), circadian rhythms (Project 2), and uterine magnetic resonance imaging and electromyometrial imaging (Project 3). Results: A total of 1260 participants were enrolled and delivered during the study period. Of the participants, 706 (56%) were Black/African American, 494 (39%) were nulliparous, and 185 (15%) had a previous preterm birth. Of the 1260 participants, 1220 (97%) delivered a live infant. Of the 1220 with a live birth, 163 (14.1%) had preterm birth, of which 74 (6.1%) were spontaneous preterm birth. Of the 1220 participants with a live birth, 841 participated in cervical imaging, 1047 contributed data and/or samples on circadian rhythms, and 39 underwent uterine magnetic resonance imaging. Of the 39, 25 underwent electromyometrial imaging. Conclusion: We demonstrate feasibility of recruiting and retaining a diverse cohort in a complex prospective, longitudinal study throughout pregnancy. The extensive clinical, imaging, survey, and biologic data obtained will be used to explore cervical, uterine, and endocrine physiology of preterm birth and can be used to develop novel approaches to predict and prevent preterm birth.

Item Type:Article
Related URLs:
URLURL TypeDescription CentralArticle ItemDiscussion Paper
Stout, Molly J.0000-0001-5171-313X
Raghuraman, Nandini0000-0003-2747-5113
Zhao, Peinan0000-0002-9716-3441
Wang, Lihong V.0000-0001-9783-4383
Cahill, Alison G.0000-0002-6012-3374
Cuculich, Phillip S.0000-0001-8127-2240
Jungheim, Emily S.0000-0003-2893-8773
Herzog, Erik D.0000-0001-7209-5174
Fay, Justin0000-0003-1893-877X
Macones, George A.0000-0002-1164-3568
England, Sarah K.0000-0003-4247-0281
Additional Information:We thank the Prematurity Research Cohort Study participants for their invaluable contributions to preterm birth research. We thank the research staff for their tireless efforts enrolling and following participants and collecting and managing data and specimens. We thank Deborah Frank, PhD, Stephanie Pizzella, Christine Kramer, and Jillian Ashley-Martin, PhD, for editorial comments and Anthony Bartley for graphical assistance. This work was supported by a research grant from the March of Dimes Foundation (to M.J. S, P.Z, M.G.T., L.V.W., A.G.C, Y.W., E.S.J., E.D.H., J.F, A.L.S., G.A.M. and S.K.E.). The cohort was make possible by support institutional support from St. Louis Children’s Hospital, Barnes-Jewish Hospital, and Washington University School of Medicine.
Funding AgencyGrant Number
March of Dimes FoundationUNSPECIFIED
St. Louis Children’s HospitalUNSPECIFIED
Foundation for Barnes-Jewish HospitalUNSPECIFIED
Washington UniversityUNSPECIFIED
Issue or Number:8
Record Number:CaltechAUTHORS:20230111-282624100.14
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:118784
Deposited By: Research Services Depository
Deposited On:06 Feb 2023 17:09
Last Modified:06 Feb 2023 17:09

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