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Synthesis of a Fe₃-Carbyne Motif by Oxidation of an Alkyl Ligated Iron-Sulfur (WFe₃S₃) Cluster

Scott, Anna G. and Agapie, Theodor (2023) Synthesis of a Fe₃-Carbyne Motif by Oxidation of an Alkyl Ligated Iron-Sulfur (WFe₃S₃) Cluster. Journal of the American Chemical Society, 145 (1). pp. 2-6. ISSN 0002-7863. doi:10.1021/jacs.2c04826.

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The presence of a carbide ligand in the active site of nitrogenases remains an unusual example of organometallic chemistry employed by a protein. Carbide incorporation into the MFe₇S₉ C cluster involves complex biosynthesis, but analogous synthetic methodologies are limited. Herein, we present a new synthetic strategy for incorporating carbon based bridging ligands into iron–sulfur clusters. Starting from a halide precursor, a WFe₃S₃ cluster displaying three terminal alkyl ligands and an open Fe₃ face was prepared. Oxidation results in loss of alkane and formation of a μ3-carbyne. Characterization of these clusters and mechanistic studies are presented.

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Agapie, Theodor0000-0002-9692-7614
Additional Information:We are grateful to the National Institutes of Health (R01-GM102687B to T.A.) and the National Science Foundation (Graduate Research Fellowships Program to A.G.S.) for funding. We thank the Beckman Institute and the Dow Next Generation Grant for instrumentation support. Michael Takase is thanked for assistance with crystallography. We are grateful to Paul Oyala for assistance with EPR experiments.
Funding AgencyGrant Number
NSF Graduate Research FellowshipUNSPECIFIED
Caltech Beckman InstituteUNSPECIFIED
Dow Next Generation Educator FundUNSPECIFIED
Issue or Number:1
Record Number:CaltechAUTHORS:20230125-515005200.29
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:118947
Deposited By: Research Services Depository
Deposited On:24 Feb 2023 17:46
Last Modified:24 Feb 2023 17:46

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