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Chromosomally directed protein synthesis

Bonner, James and Huang, Ru-Chih C. and Gilden, Ray V. (1963) Chromosomally directed protein synthesis. Proceedings of the National Academy of Sciences of the United States of America, 50 (5). pp. 893-900. ISSN 0027-8424.

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The different kinds of specialized cells of a higher organism differ among themselves in the kinds of enzymes and other proteins which they contain. Nonetheless, each possesses in the chromosomes of its nucleus the complete genomal DNA containing information concerning the manufacture of all of the kinds of enzymes contained in all of the kinds of cells of that creature. It is clear, therefore, that there is in the nucleus some mechanism for the control of genetic activity, a mechanism responsible for that orderly repression and derepression of gene activity which makes possible development. The present work concerns the control of genetic activity.

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Additional Information:© 1963 by the National Academy of Sciences. Communicated September 30, 1963. We wish to acknowledge the fine technical assistance of Stella Tan, Ludia Brown, and Abbas Soleimani, as well as the continuing helpful counsel of Professor Paul O.P. Ts'o. Report of work supported by the U.S. Public Health Service, grants RG-3977, RG-5143, and A-3102.
Funding AgencyGrant Number
Public Health ServiceRG-3977
Public Health ServiceRG-5143
Public Health ServiceA-3102
Issue or Number:5
Record Number:CaltechAUTHORS:BONpnas63
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:11907
Deposited By: Tony Diaz
Deposited On:12 Oct 2008 07:01
Last Modified:03 Oct 2019 00:23

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