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Molecular complementarity between nuclear DNA and organ-specific chromosomal RNA

Bonner, James and Widholm, Jack (1967) Molecular complementarity between nuclear DNA and organ-specific chromosomal RNA. Proceedings of the National Academy of Sciences of the United States of America, 57 (5). pp. 1379-1385. ISSN 0027-8424.

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We have shown earlier (1) that chromosomes contain RNA which is associated with the chromosomal proteins, the majority of which are histories. In pea chromatin these RNA molecules are approximately 40 nucleotides in length, contain about 27 mole per cent dihydrouridylic acid, and are associated with chromosomal DNA in such a way that they are protected from attack by RNase. As a first step in the study of the role of this class of RNA we have investigated the characteristics of its hybridization with nuclear DNA. It is shown below that the RNA component of protein-bound chromosomal RNA is heterogeneous and that it hybridizes with 5 per cent of nuclear DNA, a ratio approximating the ratio of this RNA to DNA in native chromatin.

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Additional Information:© 1967 by the National Academy of Sciences. Communicated March 29, 1967. We gratefully acknowledge the counsel and support of our colleagues Professors Norman Davidson, Jerome Vinograd, and Ru-chich C. Huang, Dr. Keiji Marushige, and Michael E. Dahmus and Douglas Fambrough. We acknowledge with pleasure the skillful assistance of Georgia Lau, Katherine Ching-Mei Ku, and Ludia Brown. Report of work supported in part by the Herman Frasch Foundation, and by the U.S. Public Health Service, grant GM-AM-13,762.
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Herman Frasch FoundationUNSPECIFIED
Public Health ServiceGM-AM-13,762
Issue or Number:5
Record Number:CaltechAUTHORS:BONpnas67
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:11908
Deposited By: Tony Diaz
Deposited On:18 Oct 2008 02:57
Last Modified:03 Oct 2019 00:23

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