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Practice Makes Imperfect: Restorative Effects of Sleep on Motor Learning

Sheth, Bhavin R. and Janvelyan, Davit and Khan, Murtuza (2008) Practice Makes Imperfect: Restorative Effects of Sleep on Motor Learning. PLoS ONE, 3 (9). Art. No. e3190. ISSN 1932-6203. PMCID PMC2527676. https://resolver.caltech.edu/CaltechAUTHORS:SHEplosone08

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Abstract

Emerging evidence suggests that sleep plays a key role in procedural learning, particularly in the continued development of motor skill learning following initial acquisition. We argue that a detailed examination of the time course of performance across sleep on the finger-tapping task, established as the paradigm for studying the effect of sleep on motor learning, will help distinguish a restorative role of sleep in motor skill learning from a proactive one. Healthy subjects rehearsed for 12 trials and, following a night of sleep, were tested. Early training rapidly improved speed as well as accuracy on pre-sleep training. Additional rehearsal caused a marked slow-down in further improvement or partial reversal in performance to observed levels below theoretical upper limits derived on the basis of early pre-sleep rehearsal. This decrement in learning efficacy does not occur always, but if and only if it does, overnight sleep has an effect in fully or partly restoring the efficacy and actual performance to the optimal theoretically achieveable level. Our findings re-interpret the sleep-dependent memory enhancement in motor learning reported in the literature as a restoration of fatigued circuitry specialized for the skill. In providing restitution to the fatigued brain, sleep eliminates the rehearsal-induced synaptic fatigue of the circuitry specialized for the task and restores the benefit of early pre-sleep rehearsal. The present findings lend support to the notion that latent sleep-dependent enhancement of performance is a behavioral expression of the brain's restitution in sleep.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1371/journal.pone.0003190DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2527676/PubMed CentralArticle
Additional Information:© 2008 Sheth et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Received: March 26, 2008; Accepted: May 6, 2008; Published: September 12, 2008. We thank Shinsuke Shimojo at the California Institute of Technology (Caltech) in whose laboratory some of the data were collected. Author Contributions: Conceived and designed the experiments: BS. Performed the experiments: DJ MK. Analyzed the data: BS DJ. Wrote the paper: BS. This research was supported in part by funds from the University of Houston (BRS) and a Cline Discovery Grant (BRS, Caltech). MZ was supported by a UH-PURS fellowship. DJ was supported by a Caltech-SURF fellowship. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Competing interests: The authors have declared that no competing interests exist.
Funders:
Funding AgencyGrant Number
University of HoustonUNSPECIFIED
Cline Discovery GrantUNSPECIFIED
Caltech Summer Undergraduate Research Fellowship (SURF)UNSPECIFIED
Issue or Number:9
PubMed Central ID:PMC2527676
Record Number:CaltechAUTHORS:SHEplosone08
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:SHEplosone08
Usage Policy:© 2008 Sheth et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
ID Code:11919
Collection:CaltechAUTHORS
Deposited By: Archive Administrator
Deposited On:09 Oct 2008 22:45
Last Modified:12 Feb 2020 21:35

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