Buss, Marjorie T. and Hurt, Robert C. and Duan, Mengtong (2023) Real-time monitoring of tumor-homing bacteria and tumor cells in vivo using ultrasound. Nature Biotechnology . ISSN 1087-0156. doi:10.1038/s41587-022-01590-x. (In Press) https://resolver.caltech.edu/CaltechAUTHORS:20230213-466109600.34
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Abstract
By screening natural prokaryotic gas vesicle gene clusters, we found and engineered new acoustic reporter genes (ARGs) that give bacteria and mammalian cells brighter ultrasound contrast for real-time noninvasive imaging. Expressing these ARGs in engineered cells enabled us to image tumor-homing bacteria and perform genetically guided tumor biopsies in vivo.
| Item Type: | Article | |||||||||
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| DOI: | 10.1038/s41587-022-01590-x | |||||||||
| Record Number: | CaltechAUTHORS:20230213-466109600.34 | |||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20230213-466109600.34 | |||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
| ID Code: | 119255 | |||||||||
| Collection: | CaltechAUTHORS | |||||||||
| Deposited By: | Research Services Depository | |||||||||
| Deposited On: | 23 Mar 2023 23:59 | |||||||||
| Last Modified: | 23 Mar 2023 23:59 |
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