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Slow synaptic transmission in frog sympathetic ganglia

Adams, P. R. and Jones, S. W. and Pennefeather, P. and Brown, D. A. and Koch, Christof and Lancaster, B. (1986) Slow synaptic transmission in frog sympathetic ganglia. Journal of Experimental Biology, 124 . pp. 259-285. ISSN 0022-0949.

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Bullfrog ganglia contain two classes of neurone, B and C cells, which receive different inputs and exhibit different slow synaptic potentials. B cells, to which most effort has been directed, possess slow and late slow EPSPs. The sEPSP reflects a muscarinic action of acetylcholine released from boutons on B cells, whereas the late sEPSP is caused by a peptide (similar to teleost LHRH) released from boutons on C cells. During either sEPSP there is a selective reduction in two slow potassium conductances, designated 'M' and 'AHP'. The M conductance is voltage dependent and the AHP conductance is calcium dependent. Normally they act synergistically to prevent repetitive firing of action potentials during maintained stimuli. Computer stimulation of the interactions of these conductances with the other five voltage-dependent conductances present in the membrane allows a complete reconstruction of the effects of slow synaptic transmission on electrical behaviour.

Item Type:Article
Related URLs:
URLURL TypeDescription
Brown, D. A.0000-0002-9180-5765
Koch, Christof0000-0001-6482-8067
Additional Information:Copyright © 1986 by Company of Biologists. This work was supported by NIH grants NS 18579 (PRA) and NS 20751 (SWJ). The manuscript was prepared during a visit to the Instituto de Investigaciones Bioquimicas, Bahia Blanca, supported by the CONICET of Argentina. PRA thanks F. J. Barrantes for his hospitality and M. H. Salaberry de Saint-Lary and L. Nielsen for their help with the manuscript. Further help was provided by Dahl Capello.
Group:Koch Laboratory (KLAB)
Funding AgencyGrant Number
NIHNS 18579
NIHNS 20751
Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)UNSPECIFIED
Subject Keywords:sympathetic ganglion, slow EPSP, muscarinic receptor
Record Number:CaltechAUTHORS:ADAjeb86
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:11999
Deposited By: Archive Administrator
Deposited On:16 Oct 2008 23:56
Last Modified:09 Mar 2020 13:18

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