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Single-neuron spiking variability in hippocampus dynamically tracks sensory content during memory formation in humans

Waschke, Leonhard and Kamp, Fabian and van den Elzen, Evi and Krishna, Suresh and Lindenberger, Ulman and Rutishauser, Ueli and Garrett, Douglas D. (2023) Single-neuron spiking variability in hippocampus dynamically tracks sensory content during memory formation in humans. . (Unpublished)

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During memory formation, the hippocampus is presumed to represent the “content” of stimuli, but how it does so is unknown. Using computational modelling and human single-neuron recordings, we show that the more precisely hippocampal spiking variability tracks the composite features that comprise each individual stimulus, the better those stimuli are later remembered. We propose that moment-to-moment spiking variability may provide a new window into how the hippocampus constructs memories from the building blocks of our sensory world.

Item Type:Report or Paper (Discussion Paper)
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URLURL TypeDescription Paper
Waschke, Leonhard0000-0002-1248-9259
van den Elzen, Evi0000-0003-4325-2497
Lindenberger, Ulman0000-0001-8428-6453
Rutishauser, Ueli0000-0002-9207-7069
Garrett, Douglas D.0000-0002-0629-7672
Additional Information:The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license. We thank Morgan Barense, Ulrich Mayr, and Markus Werkle-Bergner for fruitful discussions on earlier versions of this work. LW, FK, and DDG were partially funded by an Emmy Noether Program grant from the German Research Foundation (to DDG) and by the Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin. UR was partially supported by NIH NINDS U01NS117839. Data and code availability. Analysed data have been published previously and can be downloaded ( Code to reproduce all main results will be made accessible on Github upon publication. The authors have declared no competing interest.
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Deutsche Forschungsgemeinschaft (DFG)UNSPECIFIED
Max Planck Institute for Human DevelopmentUNSPECIFIED
Record Number:CaltechAUTHORS:20230316-182104000.12
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:120131
Deposited By: George Porter
Deposited On:22 Mar 2023 16:16
Last Modified:22 Mar 2023 16:16

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