Waschke, Leonhard and Kamp, Fabian and van den Elzen, Evi and Krishna, Suresh and Lindenberger, Ulman and Rutishauser, Ueli and Garrett, Douglas D. (2023) Single-neuron spiking variability in hippocampus dynamically tracks sensory content during memory formation in humans. . (Unpublished) https://resolver.caltech.edu/CaltechAUTHORS:20230316-182104000.12
![]() |
PDF
- Submitted Version
Creative Commons Attribution Non-commercial No Derivatives. 2MB |
Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:20230316-182104000.12
Abstract
During memory formation, the hippocampus is presumed to represent the “content” of stimuli, but how it does so is unknown. Using computational modelling and human single-neuron recordings, we show that the more precisely hippocampal spiking variability tracks the composite features that comprise each individual stimulus, the better those stimuli are later remembered. We propose that moment-to-moment spiking variability may provide a new window into how the hippocampus constructs memories from the building blocks of our sensory world.
Item Type: | Report or Paper (Discussion Paper) | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Related URLs: |
| ||||||||||||
ORCID: |
| ||||||||||||
Additional Information: | The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license. We thank Morgan Barense, Ulrich Mayr, and Markus Werkle-Bergner for fruitful discussions on earlier versions of this work. LW, FK, and DDG were partially funded by an Emmy Noether Program grant from the German Research Foundation (to DDG) and by the Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin. UR was partially supported by NIH NINDS U01NS117839. Data and code availability. Analysed data have been published previously and can be downloaded (https://europepmc.org/article/pmc/pmc5810422). Code to reproduce all main results will be made accessible on Github upon publication. The authors have declared no competing interest. | ||||||||||||
Funders: |
| ||||||||||||
DOI: | 10.1101/2023.02.23.529684 | ||||||||||||
Record Number: | CaltechAUTHORS:20230316-182104000.12 | ||||||||||||
Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20230316-182104000.12 | ||||||||||||
Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||||||
ID Code: | 120131 | ||||||||||||
Collection: | CaltechAUTHORS | ||||||||||||
Deposited By: | George Porter | ||||||||||||
Deposited On: | 22 Mar 2023 16:16 | ||||||||||||
Last Modified: | 22 Mar 2023 16:16 |
Repository Staff Only: item control page