A Caltech Library Service

Differential Stability of Task Variable Representations in Retrosplenial Cortex

Franco, Luis M. and Goard, Michael J. (2022) Differential Stability of Task Variable Representations in Retrosplenial Cortex. . (Unpublished)

[img] PDF - Submitted Version
Creative Commons Attribution No Derivatives.


Use this Persistent URL to link to this item:


Cortical neurons store information across different timescales, from seconds to years. Although information stability is variable across regions, it can vary within a region as well. Association areas are known to multiplex behaviorally relevant variables, but the stability of their representations is not well understood. Here, we longitudinally recorded the activity of neuronal populations in the retrosplenial cortex (RSC) during the performance of a context-choice association task. We found that the activity of neurons exhibits different levels of stability across days. Using linear classifiers, we quantified the stability of three task relevant variables. We find that RSC representations of context and trial outcome display higher stability than motor choice, both at the single cell and population levels. Together, our findings show an important characteristic of association areas, where diverse information is stored with varying levels of stability, maintaining an adequate balance between stability and flexibility to subserve behavioral demands.

Item Type:Report or Paper (Discussion Paper)
Related URLs:
URLURL TypeDescription Paper
Franco, Luis M.0000-0003-3156-8320
Goard, Michael J.0000-0002-5366-8501
Additional Information:The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license. We would like to thank Ralf Wessel and Tina Xia for comments on manuscript. This work was supported by the following: Harvey Karp Discovery Award (L.M.F.), UC MEXUS-CONACYT Postdoctoral Fellowship (L.M.F.), NIH R01 RF1NS121919 (M.J.G.), NSF 1707287 (M.J.G.), Larry L. Hillblom Foundation (M.J.G.), and Whitehall Foundation (M.J.G.). AUTHOR CONTRIBUTIONS. L.M.F. and M.J.G. designed the experiments; L.M.F. performed the surgical implants; L.M.F. conducted the experiments and analyzed the data; L.M.F. and M.J.G. wrote the manuscript. DATA AVAILABILITY. All processed imaging data used for making Figures 1-5 is available in the following repository: (url to be posted upon acceptance) The authors have declared no competing interest.
Funding AgencyGrant Number
University of California, Santa BarbaraUNSPECIFIED
University of California Alianza MXUNSPECIFIED
NIHR01 RF1NS121919
Larry L. Hillblom FoundationUNSPECIFIED
Whitehall FoundationUNSPECIFIED
Record Number:CaltechAUTHORS:20230322-101510000.11
Persistent URL:
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:120308
Deposited By: George Porter
Deposited On:22 Mar 2023 23:34
Last Modified:22 Mar 2023 23:34

Repository Staff Only: item control page