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The Caenorhabditis elegans lin-12 gene mediates induction of ventral uterine specialization by the anchor cell

Newman, Anna P. and White, John G. and Sternberg, Paul W. (1995) The Caenorhabditis elegans lin-12 gene mediates induction of ventral uterine specialization by the anchor cell. Development, 121 (2). pp. 263-271. ISSN 0950-1991.

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The anchor cell (AC) of the Caenorhabditis elegans gonad has a critical role in the development of a functional egg-laying system, which is accomplished through cell-cell interactions. Lateral inhibitory lin-12-mediated signaling among two bipotential cells causes one to adopt the ventral uterine precursor (VU) cell fate while the other becomes the AC. The AC then induces formation of vulval tissue. We find that the AC also induces a particular ventral uterine intermediate precursor fate (pi) by a mechanism that is genetically and temporally distinct from vulval induction. This process requires lin-12, but unlike previously described lin-12-mediated decisions, signaling is unidirectional, is between dissimilar cells and does not involve lateral inhibition. The pi fates are necessary for egg laying and appear to produce a distinct specialized cell type. Thus, patterning of the ventral uterus by the AC is crucial to the development of a functional egg-laying system.

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Sternberg, Paul W.0000-0002-7699-0173
Additional Information:Copyright © 1995 by Company of Biologists. (Accepted 31 October 1994) We thank Eileen Southgate and Douglas Kershaw for the EM reconstructions of the lin-12 mutant animals. Thanks to D. Anderson, N. Bonini, H. Lester, H. Lipshitz and members of our laboratories for their comments on the manuscript. We are grateful to M. Han, J. Kimble, E. Lambie and T. Schedl for sending us strains. This research was supported by the Howard Hughes Medical Institute. P.W.S. is an investigator of the Howard Hughes Medical Institute. A.P.N. was a USPHS postdoctoral fellow.
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Howard Hughes Medical InstituteUNSPECIFIED
Public Health ServiceUNSPECIFIED
Subject Keywords:Caenorhabditis, lin-12, anchor cell, uterine development, induction
Issue or Number:2
Record Number:CaltechAUTHORS:NEWdev95
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:12031
Deposited By: Archive Administrator
Deposited On:20 Oct 2008 20:59
Last Modified:03 Mar 2020 13:01

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