A Caltech Library Service

A stretchable wireless wearable bioelectronic system for multiplexed monitoring and combination treatment of infected chronic wounds

Shirzaei Sani, Ehsan and Xu, Changhao and Wang, Canran and Song, Yu and Min, Jihong and Tu, Jiaobing and Solomon, Samuel A. and Li, Jiahong and Banks, Jaminelli L. and Armstrong, David G. and Gao, Wei (2023) A stretchable wireless wearable bioelectronic system for multiplexed monitoring and combination treatment of infected chronic wounds. Science Advances, 9 (12). Art. No. eadf7388. ISSN 2375-2548. PMCID PMC10038347. doi:10.1126/sciadv.adf7388.

[img] PDF - Published Version
Creative Commons Attribution.

[img] PDF (Materials and Methods; Notes S1 and S2; Figs. S1 to S32; Legend for movie S1; References) - Supplemental Material
Creative Commons Attribution.

[img] Archive (ZIP) (Movie S1) - Supplemental Material
Creative Commons Attribution.


Use this Persistent URL to link to this item:


Chronic nonhealing wounds are one of the major and rapidly growing clinical complications all over the world. Current therapies frequently require emergent surgical interventions, while abuse and misapplication of therapeutic drugs often lead to an increased morbidity and mortality rate. Here, we introduce a wearable bioelectronic system that wirelessly and continuously monitors the physiological conditions of the wound bed via a custom-developed multiplexed multimodal electrochemical biosensor array and performs noninvasive combination therapy through controlled anti-inflammatory antimicrobial treatment and electrically stimulated tissue regeneration. The wearable patch is fully biocompatible, mechanically flexible, stretchable, and can conformally adhere to the skin wound throughout the entire healing process. Real-time metabolic and inflammatory monitoring in a series of preclinical in vivo experiments showed high accuracy and electrochemical stability of the wearable patch for multiplexed spatial and temporal wound biomarker analysis. The combination therapy enabled substantially accelerated cutaneous chronic wound healing in a rodent model.

Item Type:Article
Related URLs:
URLURL TypeDescription CentralArticle InCaltech News
Shirzaei Sani, Ehsan0000-0002-4609-1505
Xu, Changhao0000-0002-6817-3341
Wang, Canran0000-0003-3297-9041
Song, Yu0000-0002-4185-2256
Min, Jihong0000-0002-5788-1473
Tu, Jiaobing0000-0002-7653-6640
Solomon, Samuel A.0000-0001-7199-6659
Li, Jiahong0000-0001-7938-9589
Gao, Wei0000-0002-8503-4562
Additional Information:© 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). We gratefully acknowledge critical support and infrastructure provided for this work by the Kavli Nanoscience Institute and the Biological Imaging Facility at the Beckman Institute at Caltech. This work was supported by National Institutes of Health grant R01HL155815 (W.G.), National Institutes of Health grant R21DK13266 (W.G.), National Science Foundation grant 2145802 (W.G.), Office of Naval Research grant N00014-21-1-2483 (W.G.), Office of Naval Research grant N00014-21-1-2845 (W.G.), Heritage Medical Research Institute at the California Institute of Technology (Caltech) (W.G.), Donna and Benjamin M. Rosen Bioengineering Center at Caltech (W.G.), Rothenberg Innovation Initiative at Caltech (W.G.), Sloan Research Fellowship. Author contributions: Conceptualization: W.G. and E.S.S. Supervision: W.G. Methodology: W.G., E.S.S., and C.X. Investigation: E.S.S., C.X., C.W., Y.S., J.M., J.T., S.A.S., J.L., J.L.B., and D.G.A. Funding acquisition: W.G. Writing—original draft: W.G., E.S.S., and C.X. Writing—review and editing: C.W., Y.S., J.M., J.T., S.A.S., J.L., J.L.B., and D.G.A. Competing interests: E.S.S. and W.G. are inventors of a patent application through California Institute of Technology describing the system and technology under the U.S. provisional patent application no. 17/993,743 (filed on 23 November 2022). The authors declare that they have no other competing interests.
Group:Kavli Nanoscience Institute, Heritage Medical Research Institute, Rosen Bioengineering Center
Funding AgencyGrant Number
Office of Naval Research (ONR)N00014-21-1-2483
Office of Naval Research (ONR)N00014-21-1-2845
Heritage Medical Research InstituteUNSPECIFIED
Donna and Benjamin M. Rosen Bioengineering CenterUNSPECIFIED
Rothenberg Innovation Initiative (RI2)UNSPECIFIED
Alfred P. Sloan FoundationUNSPECIFIED
Issue or Number:12
PubMed Central ID:PMC10038347
Record Number:CaltechAUTHORS:20230328-625234000.1
Persistent URL:
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:120488
Deposited By: George Porter
Deposited On:30 Mar 2023 15:52
Last Modified:30 Mar 2023 15:52

Repository Staff Only: item control page