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The structure of a new metabolic derivative of quinine

Mead, James and Koepfli, J. B. (1944) The structure of a new metabolic derivative of quinine. Journal of Biological Chemistry, 154 (3). pp. 507-515. ISSN 0021-9258.

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The isolation and crystallization of a product obtained by the in vitro action of rabbit liver on quinine (I) have recently been described by Kelsey, Geiling, Oldham, and Dearborn (1). The work reported here was undertaken with the object of obtaining information, as rapidly as possible, as to the possible structure of this product, which might prove useful in other malarial investigations. Thus no attempt has been made to obtain or present a rigid proof of structure of the metabolic product, which, for convenience, will be referred to as QDP (quinine-derived product). Evidence will be presented which suggests that QDP is levorotatory 2’-hydroxy-6’-methoxy-3-vinylruban-9-ol (II), according to the notation introduced by Rabe (2).

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Additional Information:© 1944 American Society of Biological Chemists. Received for publication, March 13, 1944. The authors are indebted to Dr. F.E. Kelsey, Dr. E.M.K. Geiling, Dr. Frances K. Oldham, and Dr. Earl H. Dearborn of the University of Chicago for the gift of a generous sample of their metabolic derivative of quinine and to Mr. William Saschek, College of Physicians and Surgeons, Columbia University, for the microanalyses reported here. This work was done under a contract, recommended by the Committee on Medical Research, between the Office of Scientific Research and Development and the California Institute of Technology. Gates and Crellin Laboratories of Chemistry, Contribution No. 958.
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Gates and Crellin Laboratories of Chemistry958
Issue or Number:3
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:12081
Deposited By: Tony Diaz
Deposited On:27 Oct 2008 18:19
Last Modified:03 Oct 2019 00:25

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