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The synthesis of potential antimalarials. Derivatives of pantoyltaurine

Mead, J. F. and Rapport, M. M. and Senear, A. E. and Maynard, J. T. and Koepfli, J. B. (1946) The synthesis of potential antimalarials. Derivatives of pantoyltaurine. Journal of Biological Chemistry, 163 (2). pp. 465-473. ISSN 0021-9258.

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The general hypothesis as to the mode of action of chemotherapeutic agents, which has been formulated by Fildes, Woods, McIlwain, and others (2), offers a rational and useful guide to the design of new drugs. Thus, bacteriostasis is pictured as caused by the blocking of reactions essential to growth by an inhibiting substance which has a structure similar to that of one of the normal enzymes or metabolites essential to the growth of the organism.

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Additional Information:© 1946 American Society of Biological Chemists. Received for publication, January 22, 1946. The authors wish to thank Dr. William Trager of the Rockefeller Institute, Princeton, New Jersey, for his encouragement and suggestions and Dr. Carl Niemann and Dr. Edwin Buchman of this Institute for their advice and technical aid. We are indebted to Merck and Company, Inc., for a generous gift of l-pantolactone and 2-aminothiazole, to the American Cyanamid Company for a gift of 2-aminopyrimidine, and to Armour and Company for a gift of octadecylamine. The microanalyses, except where indicated, were performed by Dr. Gertrude Oppenheimer of this Institute. The work was done under a contract, recommended by the Committee on Medical Research, between the Office of Scientific Research and Development and the California Institute of Technology. The paper was submitted to the Advisory Committee on Publications, National Research Council, October 20, 1943. Gates and Crellin Laboratories of Chemistry, Contribution No. 949.
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Gates and Crellin Laboratories of Chemistry949
Issue or Number:2
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ID Code:12082
Deposited By: Tony Diaz
Deposited On:27 Oct 2008 18:14
Last Modified:03 Oct 2019 00:25

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