CaltechAUTHORS
  A Caltech Library Service

Dissociating the Role of the Orbitofrontal Cortex and the Striatum in the Computation of Goal Values and Prediction Errors

Hare, Todd A. and O'Doherty, John P. and Camerer, Colin F. and Schultz, Wolfram and Rangel, Antonio (2008) Dissociating the Role of the Orbitofrontal Cortex and the Striatum in the Computation of Goal Values and Prediction Errors. Journal of Neuroscience, 28 (22). pp. 5623-5630. ISSN 0270-6474. PMCID PMC6670807. https://resolver.caltech.edu/CaltechAUTHORS:HARjns08

[img]
Preview
PDF - Published Version
Creative Commons Attribution Non-commercial Share Alike.

305Kb
[img]
Preview
PDF (Supplemental Legend) - Supplemental Material
Creative Commons Attribution Non-commercial Share Alike.

30Kb
[img]
Preview
Image (GIF) (Supplemental Figure) - Supplemental Material
Creative Commons Attribution Non-commercial Share Alike.

55Kb

Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:HARjns08

Abstract

To make sound economic decisions, the brain needs to compute several different value-related signals. These include goal values that measure the predicted reward that results from the outcome generated by each of the actions under consideration, decision values that measure the net value of taking the different actions, and prediction errors that measure deviations from individuals' previous reward expectations. We used functional magnetic resonance imaging and a novel decision-making paradigm to dissociate the neural basis of these three computations. Our results show that they are supported by different neural substrates: goal values are correlated with activity in the medial orbitofrontal cortex, decision values are correlated with activity in the central orbitofrontal cortex, and prediction errors are correlated with activity in the ventral striatum.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1523/JNEUROSCI.1309-08.2008DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6670807PubMed CentralArticle
ORCID:
AuthorORCID
O'Doherty, John P.0000-0003-0016-3531
Camerer, Colin F.0000-0003-4049-1871
Additional Information:Copyright © 2008 Society for Neuroscience. Received January 8, 2008; accepted April 21, 2008. This work was supported by the Moore Foundation.
Funders:
Funding AgencyGrant Number
Gordon and Betty Moore FoundationUNSPECIFIED
Subject Keywords:decision making; neuroeconomics; fMRI; goal values; decision values; prediction errors
Issue or Number:22
PubMed Central ID:PMC6670807
Record Number:CaltechAUTHORS:HARjns08
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:HARjns08
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:12195
Collection:CaltechAUTHORS
Deposited By: Archive Administrator
Deposited On:28 Oct 2008 22:18
Last Modified:03 Oct 2019 00:26

Repository Staff Only: item control page