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Higher-Order Cellular Information Processing with Synthetic RNA Devices

Win, Maung Nyan and Smolke, Christina D. (2008) Higher-Order Cellular Information Processing with Synthetic RNA Devices. Science, 322 (5900). pp. 456-460. ISSN 0036-8075. doi:10.1126/science.1160311.

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The engineering of biological systems is anticipated to provide effective solutions to challenges that include energy and food production, environmental quality, and health and medicine. Our ability to transmit information to and from living systems, and to process and act on information inside cells, is critical to advancing the scale and complexity at which we can engineer, manipulate, and probe biological systems. We developed a general approach for assembling RNA devices that can execute higher-order cellular information processing operations from standard components. The engineered devices can function as logic gates (AND, NOR, NAND, or OR gates) and signal filters, and exhibit cooperativity. RNA devices process and transmit molecular inputs to targeted protein outputs, linking computation to gene expression and thus the potential to control cellular function.

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Smolke, Christina D.0000-0002-5449-8495
Additional Information:© 2008 American Association for the Advancement of Science. 12 May 2008; accepted 12 August 2008. We thank Y. Chen, J. Liang, and D. Endy for critical reading of the manuscript and A. Babiskin for pRzS. This work was supported by the Center for Biological Circuit Design at the California Institute of Technology, the Arnold and Mabel Beckman Foundation, and the NIH. The authors declare competing financial interests in the form of a pending patent application.
Funding AgencyGrant Number
Caltech Center for Biological Circuit DesignUNSPECIFIED
Arnold and Mabel Backman FoundationUNSPECIFIED
Issue or Number:5900
Record Number:CaltechAUTHORS:WINsci08
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:12219
Deposited By: Archive Administrator
Deposited On:29 Oct 2008 21:42
Last Modified:08 Nov 2021 22:26

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