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Dimethylthetin and dimethyl-β-propriothetin in methionine synthesis

Dubnoff, Jacob W. and Borsook, Henry (1948) Dimethylthetin and dimethyl-β-propriothetin in methionine synthesis. Journal of Biological Chemistry, 176 (2). pp. 789-796. ISSN 0021-9258.

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In a previous communication it was shown that choline and betaine are effective in promoting methionine synthesis from homocysteine in tissue homogenates (1). Data presented in this paper indicate that dimethylthetin, (CH3)2+SCH2COO-, which has been shown by Welch (2) to be lipotropic and has been reported by du Vigneaud (3) to promote growth on a methionine-free, homocysteine-containing diet, is 20 times as active as betaine in methionine formation. Dimethyl-β-propiothetin, (CH3)2+S(CH2)2COO-, recently isolated from Polysiphonia fastigiata by Challenger and Simpson (4) is also highly active. The enzyme for this transmethylation is found in the liver and kidney of all animals tested. Its high activity and general distribution suggest its biological importance in methionine synthesis.

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Additional Information:Copyright © 1948 American Society of Biological Chemists. (Received for publication, May 5, 1948) Presented before the meeting of the American Society of Biological Chemists at Atlantic City, March 15-19, 1947. Aided by a grant from the United States Public Health Service.
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Issue or Number:2
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:12251
Deposited By: Archive Administrator
Deposited On:30 Oct 2008 23:57
Last Modified:03 Oct 2019 00:26

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