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The p-aminobenzoic acid requirement of the "sulfonamide-requiring" mutant strain of Neurospora

Zalokar, Marko (1948) The p-aminobenzoic acid requirement of the "sulfonamide-requiring" mutant strain of Neurospora. Proceedings of the National Academy of Sciences of the United States of America, 34 (2). pp. 32-36. ISSN 0027-8424. PMCID PMC1062910. doi:10.1073/pnas.34.2.32.

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Emerson and Cushing (1) isolated a strain of Neurospora which instead of being inhibited in growth by sulfonamides requires the drug for growth at high temperatures. It seemed as if the roles of p-aminobenzoic acid (PABA) and sulfanilamide (SA) were reversed,(2) the mold being poisoned by PABA and this action being antagonized by SA. The evidence suggested that SA took the place of PABA as a metabolite.

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Additional Information:© 1948 by the National Academy of Sciences. Communicated by G.W. Beadle, December 13, 1947. The author wishes to express his indebtedness to Dr. Sterling Emerson for suggesting the problem and for offering advice and help throughout the course of the work. Representing work supported in part by a grant from the American Cancer Society upon the recommendation of the Committee on Growth of the National Research Council.
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American Cancer SocietyUNSPECIFIED
Issue or Number:2
PubMed Central ID:PMC1062910
Record Number:CaltechAUTHORS:ZALpnas48
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Official Citation:The p-Aminobenzoic Acid Requirement of the “Sulfonamide-Requiring” Mutant Strain of Neurospora Marko Zalokar Proceedings of the National Academy of Sciences Feb 1948, 34 (2) 32-36; DOI: 10.1073/pnas.34.2.32
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:12289
Deposited By: Tony Diaz
Deposited On:14 Nov 2008 04:25
Last Modified:08 Nov 2021 22:27

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