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Some of the oxidation-reduction properties of the chorionic gonadotropic hormone

Bowman, Donald E. (1941) Some of the oxidation-reduction properties of the chorionic gonadotropic hormone. Journal of Biological Chemistry, 137 (1). pp. 293-302. ISSN 0021-9258.

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Gurin, Bachman, and Wilson (1-3) have recently made important contributions to our knowledge of the chemical nature of the gonadotropic hormone of pregnancy urine. They have given a method for the preparation of the hormone in a highly purified form and have described many of its outstanding chemical and physical properties. We have been especially interested in the reference of these authors to the unexplained, continuous, and apparently spontaneous inactivation of their highly purified material which takes place, particularly in aqueous solution, without, detectable loss or rupture of certain portions of the molecule (3). Earlier communications (4-6) have called attention to our observations relative to the oxidation and inactivation of a reducing factor of pregnancy urine which appears to be the chorionic gonadotropic hormone. Some of our more recent findings appear to shed light upon the observations of the above authors. The spontaneous oxidation of this reducing factor proceeds at a very slow rate but is more rapid in aqueous solution than in urine, where other stronger reducing agents tend to protect it. If activating agents are added and moderate heat is applied, the activity becomes of sufficient magnitude to bring about the reduction of dilute solutions of iodine or other oxidants. The object of this paper is to describe some of the rather unusual characteristics of this oxidation-reduction system.

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Additional Information:Copyright © 1941 by the American Society of Biological Chemists. (Received for publication, August 21, 1940) The author wishes again to thank Dr. Henry Borsook of the California Institute of Technology for much valuable advice in relation to the electrometric studies, and also for facilities which were kindly made available for this phase of the work during the summers of 1937 and 1939.
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Deposited On:25 Nov 2008 21:50
Last Modified:03 Oct 2019 00:28

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