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G protein diversity is increased by associations with a variety of gamma subunits

Gautam, Narasimha and Northup, John and Tamir, Haya and Simon, Melvin I. (1990) G protein diversity is increased by associations with a variety of gamma subunits. Proceedings of the National Academy of Sciences of the United States of America, 87 (20). pp. 7973-7977. ISSN 0027-8424. PMCID PMC54874. doi:10.1073/pnas.87.20.7973.

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Guanine nucleotide-binding regulatory proteins (G proteins) are heterotrimeric proteins that transduce extracellular signals into intracellular changes. Functionally different G proteins have been identified by their different a subunits. The β and γ subunits have been assumed to constitute a common pool shared among various G protein heterotrimers. Two γ subunits (γ3 and γ4) have been identified through molecular cloning; these are in addition to two subunits (γ1, and γ2) that were previously characterized. G proteins purified from a variety of mammalian tissues were examined with antisera specific to three of the γ subunits. The antisera react with different γ subunits associated with some of the purified G proteins but not all. This demonstrates that different G protein heterotrimers from different tissues carry structurally distinct members of the γ-subunit family. Diversity in the structure of the γ as well as the α and β subunits and preferential associations between members of subunit families increase structural and possibly functional diversity of G proteins.

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Additional Information:© 1990 National Academy of Sciences. Contributed by Melvin I. Simon, July 26, 1990. We thank Carol Lee for assistance with sequencing; Ryn Miake-Lye and Tom Wilkie for materials; and Tom Amatruda, Bob Bourret, Michael Strathmann, and Tom Wilkie for discussions. This work was supported by National Institutes of Health Grant GM 34236. J.N. is an established investigator of the American Heart Association and is supported by National Institutes of Health Grant G40154. The sequence reported in this paper has been deposited in the GenBank data base (accession no. M37182). The publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. §1734 solely to indicate this fact.
Funding AgencyGrant Number
NIHGM 34236
NIHGM 40154
American Heart AssociationUNSPECIFIED
Issue or Number:20
PubMed Central ID:PMC54874
Record Number:CaltechAUTHORS:GAUpnas90
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:12498
Deposited By: Tony Diaz
Deposited On:18 Dec 2008 04:04
Last Modified:08 Nov 2021 22:29

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