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Ror receptor tyrosine kinases: orphans no more

Green, Jennifer L. and Kuntz, Steven G. and Sternberg, Paul W. (2008) Ror receptor tyrosine kinases: orphans no more. Trends in Cell Biology, 18 (11). pp. 536-544. ISSN 0962-8924. PMCID PMC4672995.

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Receptor tyrosine kinase-like orphan receptor (Ror) proteins are a conserved family of tyrosine kinase receptors that function in developmental processes including skeletal and neuronal development, cell movement and cell polarity. Although Ror proteins were originally named because the associated ligand and signaling pathway were unknown, recent studies in multiple species have now established that Ror proteins are Wnt receptors. Depending on the cellular context, Ror proteins can either activate or repress transcription of Wnt target genes and can modulate Wnt signaling by sequestering Wnt ligands. New evidence implicates Ror proteins in planar cell polarity, an alternative Wnt pathway. Here, we review the progress made in understanding these mysterious proteins and, in particular, we focus on their function as Wnt receptors.

Item Type:Article
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URLURL TypeDescription CentralArticle
Sternberg, Paul W.0000-0002-7699-0173
Additional Information:Copyright © 2008 Elsevier. Available online 9 October 2008. P.W.S. is an investigator with the HHMI. J.L.G. was supported by the Thomas Hunt Morgan Fellowship for graduate study toward the Doctor of Philosophy degree in Biology at the California Institute of Technology. S.G.K. was supported by NIH training grant GM07616.
Funding AgencyGrant Number
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
Thomas Hunt Morgan Fellowship, CaltechUNSPECIFIED
Issue or Number:11
PubMed Central ID:PMC4672995
Record Number:CaltechAUTHORS:GREtcb08
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:12526
Deposited By: Archive Administrator
Deposited On:16 Dec 2008 20:54
Last Modified:03 Mar 2020 13:01

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