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Thermodynamic Aspects of Flagellar Activity

Holwill, M. E. and Sleigh, M. A. (1967) Thermodynamic Aspects of Flagellar Activity. Journal of Experimental Biology, 47 (2). pp. 267-276. ISSN 0022-0949.

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1. The frequencies of the beat of cilia and flagella from various organisms have been determined at temperatures in the range 5-35°C. 2. Values of the activation enthalpy (ΔH{ddagger}, kcal./mole) and activation entropy (ΔS{ddagger}, e.u.) derived from the thermal dependence of frequency show a linear correlation of the form, ΔS{ddagger} = 3.25 ΔH{ddagger}-50.75. 3. The corresponding isokinetic activation free energy is 15.6 kcal./mole. 4. The results support a hypothesis that the breakdown of an ATP-ATPase complex could be the common rate-limiting reaction for flagellar activity. 5. Values of ΔH{ddagger} and ΔS{ddagger} for the decay of length or tension in striated muscles also fall on the same regression line but some smooth muscles show deviations.

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Additional Information:© The Company of Biologists Ltd 1967. Submitted on February 24, 1967. This work was supported in part by U.S. Public Health Service grant no. GM14631.
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Public Health ServiceGM14631
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ID Code:12593
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Deposited On:15 Dec 2008 17:15
Last Modified:03 Oct 2019 00:29

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