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On-chip temperature gradient liquid chromatography

Shih, C. Y. and Chen, Y. and Xie, J. and He, Q. and Tai, Y. C. (2005) On-chip temperature gradient liquid chromatography. In: IEEE International Conference on Micro Electro Mechanical Systems, 18th (MEMS 2005), Miami, FL, 30 January-3 February 2005. IEEE , Piscataway, NJ, pp. 782-785. ISBN 0-7803-8732-5.

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We report here the first MEMS temperature-programmable high pressure parylene column with integrated thermal isolation and electrochemical sensor for on-chip temperature gradient liquid chromatography. Two sets of devices for different high performance liquid chromatography (HPLC) criteria were fabricated. The separation and detection of derivatized amino acids sample was successfully demonstrated. Compared with other temperature gradient HPLC systems which use "macro oven" to generate temporal temperature gradient in the column, our device's thermal performance is greatly improved by orders of magnitude without the sacrifice of chromatography quality.

Item Type:Book Section
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Chen, Y.0000-0002-8964-0084
Tai, Y. C.0000-0001-8529-106X
Additional Information:© Copyright 2005 IEEE. Reprinted with permission. Publication Date: 30 Jan.-3 Feb. 2005. This work is supported by the NSF Center for Neuromorphic Systems Engineering (CNSE) at Caltech.
Funding AgencyGrant Number
Center for Neuromorphic Systems Engineering, CaltechUNSPECIFIED
Subject Keywords:chromatography; electrochemical sensors; micromechanical devices; proteins; thermal engineering; HPLC device fabrication; MEMS temperature-programmable high pressure parylene column; derivatized amino acid sample; electrochemical sensor; high performance liquid chromatography; integrated thermal isolation; on-chip temperature gradient liquid chromatography; thermal performance
Record Number:CaltechAUTHORS:SHImems05
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:12625
Deposited By: Kristin Buxton
Deposited On:16 Dec 2008 17:27
Last Modified:08 Nov 2021 22:31

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