Cohen, Donald S. and Erneux, Thomas (1988) Free boundary problems in controlled release pharmaceuticals: II. swelling-controlled release. SIAM Journal on Applied Mathematics, 48 (6). pp. 1466-1474. ISSN 0036-1399. doi:10.1137/0148090. https://resolver.caltech.edu/CaltechAUTHORS:COHsiamjam88b
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Abstract
A problem in controlled release pharmaceutical systems is formulated and studied. The device modeled is a polymer matrix containing an initially immobilized drug. The release of the drug is achieved by countercurrent diffusion through a penetrant solvent with the release rate being determined by the rate of diffusion of the solvent in the polymer. The mathematical theory yields a free boundary problem which is studied in various asymptotic regimes.
Item Type: | Article | ||||||||||||
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Additional Information: | ©1988 Society for Industrial and Applied Mathematics. Received by the editors September 10, 1986; accepted for publication (in revised form) September 16, 1987. [D.S.C] was supported in part by U.S. Army Research Office (Durham) under contract DAAG29-85-K-0092, by the National Science Foundation under grant DMS-8706642, and by the Department of Energy under grant 7405/ENG-36 at the Center for Nonlinear Studies at Los Alamos. [T.E] was supported in part by the Air Force Office of Scientific Research under grant AFOSR85-0150 and the National Science Foundation under grant DMS-8701302. | ||||||||||||
Group: | GALCIT | ||||||||||||
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Subject Keywords: | free boundaries; perturbations; polymers; controlled release | ||||||||||||
Issue or Number: | 6 | ||||||||||||
DOI: | 10.1137/0148090 | ||||||||||||
Record Number: | CaltechAUTHORS:COHsiamjam88b | ||||||||||||
Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:COHsiamjam88b | ||||||||||||
Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||||||
ID Code: | 12669 | ||||||||||||
Collection: | CaltechAUTHORS | ||||||||||||
Deposited By: | Kristin Buxton | ||||||||||||
Deposited On: | 24 Dec 2008 00:00 | ||||||||||||
Last Modified: | 08 Nov 2021 22:31 |
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