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On Mitral Valve Dynamics and its Connection to Early Diastolic Flow

Kheradvar, Arash and Gharib, Morteza (2009) On Mitral Valve Dynamics and its Connection to Early Diastolic Flow. Annals of Biomedical Engineering, 37 (1). pp. 1-13. ISSN 0090-6964.

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In the field of cardiology, the current ability to accurately detect diastolic dysfunction is unsatisfactory due to the lack of an effective diagnostic index. Isolated indexes obtained from echocardiography are all restricted to a certain aspect of ventricular diastolic function only, and individually cannot be regarded as a global representative for the left heart diastolic function. Due to complexity of cardiac motion, a reliable measure for diastolic performance should be a parameter that independently correlates with several aspects of cardiac function. The presence of trans-mitral vortex ring and its influence on dynamics of the mitral valve is a topic that has been recently received more attention in cardiovascular research. One obvious reason for this attention is to find better solutions to overcome our inability in interpretation of Doppler mitral inflow patterns for distinguishing a normal trans-mitral flow from a pseudonormal pattern. In the present study, we investigated the relationship among the ventricular early pressure drop, trans-mitral thrust as a force generated during diastolic filling and mitral annulus recoil through the index of vortex formation time. As a result, we found that vortex formation time is independently correlated to trans-mitral thrust, minimal ventricular pressure and pressure drop time-constant of isovolumic relaxation phase. Results also showed that trans-mitral thrust is maximized when the non-dimensional vortex formation time is in the range of 4 and 5.5 regardless of the shape of the waveform or the value of the pressure drop time-constant. In conclusion, this study confirms that vortex formation time, a non-dimensional measure for duration of E-wave, can be used as an index to assess diastolic ventricular function.

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Additional Information:© 2008 Biomedical Engineering Society. Received: 4 February 2008. Accepted: 17 October 2008. Published online: 4 November 2008. Authors would like to acknowledge Edwards Lifesciences Corporation for providing the bioprosthetic heart valves for this study.
Subject Keywords:Vortex formation time; Left ventricle; Trans-mitral thrust; Mitral annulus recoil
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Record Number:CaltechAUTHORS:KHEabe09
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:12875
Deposited By: Archive Administrator
Deposited On:08 Jan 2009 17:01
Last Modified:03 Oct 2019 00:32

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