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DNA-Mediated Electrochemistry

Gorodetsky, Alon A. and Buzzeo, Marisa C. and Barton, Jacqueline K. (2008) DNA-Mediated Electrochemistry. Bioconjugate Chemistry, 19 (12). pp. 2285-2296. ISSN 1043-1802. PMCID PMC2663395. https://resolver.caltech.edu/CaltechAUTHORS:GORbc08

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Abstract

The base pair stack of DNA has been demonstrated as a medium for long-range charge transport chemistry both in solution and at DNA-modified surfaces. This chemistry is exquisitely sensitive to structural perturbations in the base pair stack as occur with lesions, single base mismatches, and protein binding. We have exploited this sensitivity for the development of reliable electrochemical assays based on DNA charge transport at self-assembled DNA monolayers. Here, we discuss the characteristic features, applications, and advantages of DNA-mediated electrochemistry.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1021/bc8003149DOIArticle
http://pubs.acs.org/doi/abs/10.1021/bc8003149PublisherArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2663395/PubMed CentralArticle
ORCID:
AuthorORCID
Gorodetsky, Alon A.0000-0002-3811-552X
Barton, Jacqueline K.0000-0001-9883-1600
Additional Information:Copyright © 2008 American Chemical Society. Received July 22, 2008; Revised Manuscript Received September 2, 2008. Publication Date (Web): November 4, 2008. We gratefully acknowledge the NIH (GM61077) for their financial support. We are also very grateful to our many co-workers who have helped in elucidating this chemistry. We thank in particular Prof. M.G. Hill, without whom this chemistry could not have been discovered and described.
Funders:
Funding AgencyGrant Number
NIHGM61077
Issue or Number:12
PubMed Central ID:PMC2663395
Record Number:CaltechAUTHORS:GORbc08
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:GORbc08
Official Citation:DNA-Mediated Electrochemistry Alon A. Gorodetsky, Marisa C. Buzzeo, and Jacqueline K. Barton Bioconjugate Chemistry 2008 19 (12), 2285-2296 DOI: 10.1021/bc8003149
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:12943
Collection:CaltechAUTHORS
Deposited By: Archive Administrator
Deposited On:11 Jan 2009 05:27
Last Modified:03 Oct 2019 00:33

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