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Evidence for a low-molecular-weight collagen precursor

Bekhor, Isaac and Bavetta, Lucien A. (1967) Evidence for a low-molecular-weight collagen precursor. Proceedings of the National Academy of Sciences of the United States of America, 58 (6). pp. 2351-2358. ISSN 0027-8424.

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In this communication evidence is presented that collagen-proline hydroxylation occurs on polypeptides of low molecular weight. Thus, the hydroxylation process is initiated prior to the completion of the synthesis of collagen α-chains. The present data rule out the participation of any proteolytic enzymes in obtaining low-molecular-weight polypeptides containing hydroxyproline.

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Additional Information:Copyright © 1967 by the National Academy of Sciences. Communicated by James Bonner, September 29, 1967. The authors thank Dr. Samuel Allerton and Mr. Zia Mohseni for their extensive discussion and helpful advice in the preparation of the manuscript. This investigation was supported by U.S. Public Health Service research grants DE-00626-08 and DE-02471-01 and training grant DE-00094-05, National Institute for Dental Research. [L.A.B. was the] [r]ecipient of Career Award 5-K6-DE-6083-02, National Institute for Dental Research.
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National Institute for Dental ResearchDE-00626-08
National Institute for Dental ResearchDE-02471-01
National Institute for Dental ResearchDE-00094-05
Issue or Number:6
Record Number:CaltechAUTHORS:BEKpnas67
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:13091
Deposited By: Archive Administrator
Deposited On:17 Jan 2009 06:29
Last Modified:03 Oct 2019 00:34

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