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Tradeoff between short-term and long-term adaptation in a changing environment

Forster, Robert and Wilke, Claus O. (2005) Tradeoff between short-term and long-term adaptation in a changing environment. Physical Review E, 72 (4). Art. No. 041922. ISSN 1539-3755.

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We investigate the competition dynamics of two microbial or viral strains that live in an environment that switches periodically between two states. One of the strains is adapted to the long-term environment, but pays a short-term cost, while the other is adapted to the short-term environment and pays a cost in the long term. We explore the tradeoff between these alternative strategies in extensive numerical simulations and present a simple analytic model that can predict the outcome of these competitions as a function of the mutation rate and the time scale of the environmental changes. Our model is relevant for arboviruses, which alternate between different host species on a regular basis.

Item Type:Article
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Wilke, Claus O.0000-0002-7470-9261
Additional Information:© 2005 The American Physical Society (Received 16 December 2004; revised 15 July 2005; published 20 October 2005) This work was supported by NIH Grant NO. AI 065960.
Funding AgencyGrant Number
NIHAI 065960
Subject Keywords:microorganisms; evolution (biological)
Issue or Number:4
Record Number:CaltechAUTHORS:FORpre05
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:1336
Deposited By: Archive Administrator
Deposited On:11 Jan 2006
Last Modified:02 Oct 2019 22:42

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