CaltechAUTHORS
  A Caltech Library Service

p53 family in development

Danilova, Nadia and Sakamoto, Kathleen M. and Lin, Shuo (2008) p53 family in development. Mechanisms of Development, 125 (11-12). pp. 919-931. ISSN 0925-4773. http://resolver.caltech.edu/CaltechAUTHORS:DANmd08

Full text is not posted in this repository. Consult Related URLs below.

Use this Persistent URL to link to this item: http://resolver.caltech.edu/CaltechAUTHORS:DANmd08

Abstract

The p53 family network is a unique cellular processor that integrates information from various pathways and determines cellular choices between proliferation, replication arrest/ repair, differentiation, senescence, or apoptosis. The most studied role of the p53 family is the regulation of stress response and tumor suppression. By removing damaged cells from the proliferating pool, p53 family members preserve the integrity of the genome. In addition to this well recognized role, recent data implicate the p53 protein family in a broader role of controlling cell proliferation, differentiation and death. Members of the p53 protein family with opposing activity perform coordination of these processes. Imbalance of p53 protein family may contribute to a significant proportion of congenital developmental abnormalities in humans.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/j.mod.2008.09.003DOIArticle
ORCID:
AuthorORCID
Sakamoto, Kathleen M.0000-0003-0494-8838
Additional Information:© 2008 Elsevier Ireland Ltd. Received 22 January 2008; revised 4 September 2008; accepted 12 September 2008. Available online 20 September 2008.
Subject Keywords:p53; p63; p73; Differentiation; Proliferation; Congenital abnormalities
Record Number:CaltechAUTHORS:DANmd08
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:DANmd08
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:13373
Collection:CaltechAUTHORS
Deposited By: Jason Perez
Deposited On:09 Apr 2009 17:58
Last Modified:19 Apr 2017 23:33

Repository Staff Only: item control page