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From biophysics to cognition: reward-dependent adaptive choice behavior

Soltani, Alireza and Wang, Xiao-Jing (2008) From biophysics to cognition: reward-dependent adaptive choice behavior. Current Opinion in Neurobiology, 18 (2). pp. 209-216. ISSN 0959-4388. https://resolver.caltech.edu/CaltechAUTHORS:SOLcoin08

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Abstract

In neurobiological studies of various cognitive abilities, neuroscientists use mathematical models to fit behavioral data from well-controlled experiments and look for neural activities that are correlated with parameters in those models. The pinpointed neural correlates are often taken as evidence that a given task is performed according to the prescription of the applied model, and the relevant brain areas encode parameters of such a model. However, to go beyond correlations toward causal understanding, it is necessary to elucidate at multiple levels the neural circuit mechanisms of cognitive processes. This review focuses on recent studies of reward-based decision-making that have begun to tackle this challenge.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/j.conb.2008.07.003DOIUNSPECIFIED
Additional Information:© 2008 Published by Elsevier Ltd. Available online 21 August 2008. This work was supported by NIH grants MH073246. We thank Zahra Ayubi and Daeyeol Lee for comments on the manuscript.
Funders:
Funding AgencyGrant Number
NIHMH073246
Subject Keywords:anterior cingulate cortex; term synaptic depression; dopamine neurons encode; mixed-strategy game; decision-making; matching behavior; prefrontal cortex; corticostriatal synapses; receptor activation; superior colliculus
Issue or Number:2
Record Number:CaltechAUTHORS:SOLcoin08
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:SOLcoin08
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:13378
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:24 Apr 2009 17:21
Last Modified:03 Oct 2019 00:36

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