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Natural products as inspiration for the development of asymmetric catalysis

Mohr, Justin T. and Krout, Michael R. and Stoltz, Brian M. (2008) Natural products as inspiration for the development of asymmetric catalysis. Nature, 455 (7211). pp. 323-332. ISSN 0028-0836. PMCID PMC2562237. doi:10.1038/nature07370.

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Biologically active natural products often contain particularly challenging structural features and functionalities in terms of synthesis. Perhaps the greatest difficulties are those caused by issues of stereochemistry. A useful strategy for synthesizing such molecules is to devise methods of bond formation that provide opportunities for using enantioselective catalysis. In using this tactic, the desire for a particular target structure ultimately drives the development of catalytic methods. New enantioselective catalytic methods contribute to a greater fundamental understanding of how bonds can be constructed and lead to valuable synthetic technologies that are useful for a variety of applications.

Item Type:Article
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URLURL TypeDescription CentralArticle ReadCube access
Mohr, Justin T.0000-0002-7005-3322
Krout, Michael R.0000-0002-0539-6986
Stoltz, Brian M.0000-0001-9837-1528
Additional Information:© 2008 Nature Publishing Group. We thank the National Institute of General Medical Sciences (grant number R01GM080269-01), Eli Lilly (which provided predoctoral fellowships to J.T.M. and M.R.K.), Amgen, Abbott Laboratories, Boehringer Ingelheim, Merck, Bristol–Myers Squibb and the California Institute of Technology for financial support.
Funding AgencyGrant Number
Abbott LaboratoriesUNSPECIFIED
Boehringer IngelheimUNSPECIFIED
Bristol–Myers SquibbUNSPECIFIED
Issue or Number:7211
PubMed Central ID:PMC2562237
Record Number:CaltechAUTHORS:MOHnat08
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:13392
Deposited By: Kristin Buxton
Deposited On:16 Jun 2009 15:07
Last Modified:08 Nov 2021 22:37

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