Mohr, Justin T. and Krout, Michael R. and Stoltz, Brian M. (2008) Natural products as inspiration for the development of asymmetric catalysis. Nature, 455 (7211). pp. 323-332. ISSN 0028-0836. PMCID PMC2562237. https://resolver.caltech.edu/CaltechAUTHORS:MOHnat08
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Abstract
Biologically active natural products often contain particularly challenging structural features and functionalities in terms of synthesis. Perhaps the greatest difficulties are those caused by issues of stereochemistry. A useful strategy for synthesizing such molecules is to devise methods of bond formation that provide opportunities for using enantioselective catalysis. In using this tactic, the desire for a particular target structure ultimately drives the development of catalytic methods. New enantioselective catalytic methods contribute to a greater fundamental understanding of how bonds can be constructed and lead to valuable synthetic technologies that are useful for a variety of applications.
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Additional Information: | © 2008 Nature Publishing Group. We thank the National Institute of General Medical Sciences (grant number R01GM080269-01), Eli Lilly (which provided predoctoral fellowships to J.T.M. and M.R.K.), Amgen, Abbott Laboratories, Boehringer Ingelheim, Merck, Bristol–Myers Squibb and the California Institute of Technology for financial support. | ||||||||||||||||||
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Issue or Number: | 7211 | ||||||||||||||||||
PubMed Central ID: | PMC2562237 | ||||||||||||||||||
Record Number: | CaltechAUTHORS:MOHnat08 | ||||||||||||||||||
Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:MOHnat08 | ||||||||||||||||||
Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||||||||||||
ID Code: | 13392 | ||||||||||||||||||
Collection: | CaltechAUTHORS | ||||||||||||||||||
Deposited By: | Kristin Buxton | ||||||||||||||||||
Deposited On: | 16 Jun 2009 15:07 | ||||||||||||||||||
Last Modified: | 15 Jun 2020 19:51 |
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