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Cadherins and synaptic plasticity

Tai, Chin-Yin and Kim, Sally A. and Schuman, Erin M. (2008) Cadherins and synaptic plasticity. Current Opinion in Cell Biology, 20 (5). pp. 567-575. ISSN 0955-0674. https://resolver.caltech.edu/CaltechAUTHORS:TAIcob08

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Abstract

Given their trans-synaptic localization, their persistent expression at mature synapses and their distinct biochemical and adhesive properties, cadherins are uniquely poised at the synapse to mediate synaptic plasticity, the ability to change synaptic function thought to underlie learning and memory. For example recent work suggests that cadherins may recruit and stabilize AMPA receptors at the synapse via direct interactions or through complex formation, revealing cross talk between postsynaptic signaling and adhesion. Moreover, the use of small interfering RNA knockdown of cadherin, the availability of N-cadherin-deficient embryonic stem cells and the acute disruption of cadherin function with peptide application in vivo have allowed for more precise dissection of the molecular mechanisms by which cadherins function in both structural and functional plasticity.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/j.ceb.2008.06.003DOIUNSPECIFIED
Additional Information:© 2008 Published by Elsevier Ltd. Available online 19 July 2008. We thank Bruce Tai and Anh Pham for helpful comments on the manuscript. Work in our laboratory for this work is supported by the National Institutes of Health (MH076910-01) and the Damon Runyon Foundation. E.M.S. is an investigator of the Howard Hughes Medical Institute.
Funders:
Funding AgencyGrant Number
NIHMH076910-01
Damon Runyon FoundationUNSPECIFIED
Howard Hughes Medical InstituteUNSPECIFIED
Subject Keywords:CELL-ADHESION MOLECULES; AMPA RECEPTOR TRAFFICKING; N-CADHERIN; BETA-CATENIN; TERM PLASTICITY; BINDING PROTEIN; CLEAVAGE; CALCIUM; FAMILY; POTENTIATION
Issue or Number:5
Record Number:CaltechAUTHORS:TAIcob08
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:TAIcob08
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:13523
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:10 Jul 2009 16:51
Last Modified:03 Oct 2019 00:39

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