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Determining a Role for Ventromedial Prefrontal Cortex in Encoding Action-Based Value Signals During Reward-Related Decision Making

Gläscher, Jan and Hampton, Alan N. and O'Doherty, John P. (2009) Determining a Role for Ventromedial Prefrontal Cortex in Encoding Action-Based Value Signals During Reward-Related Decision Making. Cerebral Cortex, 19 (2). pp. 483-495. ISSN 1047–3211. PMCID PMC2626172. https://resolver.caltech.edu/CaltechAUTHORS:GLAcc09

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Abstract

Considerable evidence has emerged to implicate ventromedial prefrontal cortex in encoding expectations of future reward during value-based decision making. However, the nature of the learned associations upon which such representations depend is much less clear. Here, we aimed to determine whether expected reward representations in this region could be driven by action–outcome associations, rather than being dependent on the associative value assigned to particular discriminative stimuli. Subjects were scanned with functional magnetic resonance imaging while performing 2 variants of a simple reward-related decision task. In one version, subjects made choices between 2 different physical motor responses in the absence of discriminative stimuli, whereas in the other version, subjects chose between 2 different stimuli that were randomly assigned to different responses on a trial-by-trial basis. Using an extension of a reinforcement learning algorithm, we found activity in ventromedial prefrontal cortex tracked expected future reward during the action-based task as well as during the stimulus-based task, indicating that value representations in this region can be driven by action–outcome associations. These findings suggest that ventromedial prefrontal cortex may play a role in encoding the value of chosen actions irrespective of whether those actions denote physical motor responses or more abstract decision options.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1093/cercor/bhn098DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2626172/PubMed CentralArticle
ORCID:
AuthorORCID
Gläscher, Jan0000-0002-1020-7115
O'Doherty, John P.0000-0003-0016-3531
Additional Information:© The Author 2008. Advance Access publication June 11, 2008. The authors declare no competing financial conflict of interest. Conflict of Interest : None declared
Funders:
Funding AgencyGrant Number
Deutsche Akademie der Naturforscher Leopoldina9901/8-140
National Institute of Mental Health (NIMH)UNSPECIFIED
Gordon and Betty Moore FoundationUNSPECIFIED
Caltech Brain Imaging CenterUNSPECIFIED
NIHUNSPECIFIED
Subject Keywords:action value • decision making • reinforcement learning • reversal learning • stimulus value • ventromedial prefrontal cortex
Issue or Number:2
PubMed Central ID:PMC2626172
Record Number:CaltechAUTHORS:GLAcc09
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:GLAcc09
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:13549
Collection:CaltechAUTHORS
Deposited By: Lindsay Cleary
Deposited On:26 Feb 2009 22:11
Last Modified:25 Oct 2019 18:16

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