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Testing odor response stereotypy in the Drosophila mushroom body

Murthy, Mala and Fiete, Ila and Laurent, Gilles (2008) Testing odor response stereotypy in the Drosophila mushroom body. Neuron, 59 (6). pp. 1009-1023. ISSN 0896-6273. PMCID PMC2654402. https://resolver.caltech.edu/CaltechAUTHORS:MURneu08

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Abstract

The mushroom body is an insect brain structure required for olfactory learning. Its principal neurons, the Kenyon cells (KCs), form a large cell population. The neuronal populations from which their olfactory input derives (olfactory sensory and projection neurons) can be identified individually by genetic, anatomical, and physiological criteria. We ask whether KCs are similarly identifiable individually, using genetic markers and whole-cell patch-clamp in vivo. We find that across-animal responses are as diverse within the genetically labeled subset as across all KCs in a larger sample. These results combined with those from a simple model, using projection neuron odor responses as inputs, suggest that the precise circuit specification seen at earlier stages of odor processing is likely absent among the mushroom body KCs.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/j.neuron.2008.07.040DOIArticle
http://www.cell.com/neuron/retrieve/pii/S089662730800679XPublisherArticle
http://linkinghub.elsevier.com/retrieve/pii/S089662730800679XPublisherArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654402/PubMed CentralArticle
ORCID:
AuthorORCID
Laurent, Gilles0000-0002-2296-114X
Additional Information:© 2009 Elsevier. Accepted 8 July 2008. Published: September 24, 2008. Available online 24 September 2008. We are grateful to Kai Zinn for the use of his laboratory to rear flies and establish crosses, to Glenn Turner for help in establishing recording techniques from Kenyon cells, to Kei Ito for the gifts of NP7175-GAL4 and NP3529-GAL4, to Philip Coen for help with the anatomical identification of KCs, to the Caltech Biological Imaging Center for use of confocal microscopes, to members of the Laurent lab for advice, and to David Anderson, Benjamin Rubin, Kai Zinn, Glenn Turner, and Timothy Tayler for providing comments on this manuscript. M.M. is a Helen Hay Whitney Foundation Postdoctoral Fellow, and I.F. is a Senior Broad Fellow in Brain Circuitry. This work was funded by grants from the NIDCD, the NSF BITS Program, and the Lawrence Hanson Fund (G.L.).
Funders:
Funding AgencyGrant Number
Helen Hay Whitney FoundationUNSPECIFIED
National Institute on Deafness and Other Communication DisordersUNSPECIFIED
Lawrence Hanson FundUNSPECIFIED
Subject Keywords:mammalian olfactory-bulb; short-term-memory; antennal lobe; wiring; specificity; system; map; bodies; representations; organization; melanogaster
Issue or Number:6
PubMed Central ID:PMC2654402
Record Number:CaltechAUTHORS:MURneu08
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:MURneu08
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:13600
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:13 May 2009 18:38
Last Modified:03 Oct 2019 00:41

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