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Functional neuroanatomical investigation of vision-related acupuncture point specificity—a multisession fMRI study

Kong, Jian and Kaptchuk, Ted J. and Webb, Julia Megan and Kong, Jiang-Ti and Sasaki, Yuka and Polich, Ginger R. and Vangel, Mark G. and Kwong, Kenneth and Rosen, Bruce and Gollub, Randy L. (2009) Functional neuroanatomical investigation of vision-related acupuncture point specificity—a multisession fMRI study. Human Brain Mapping, 30 (1). pp. 38-46. ISSN 1065-9471. https://resolver.caltech.edu/CaltechAUTHORS:KONhbm09

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Abstract

The concept that specific acupuncture points have salubrious effects on distant target organ systems is a salient feature of Traditional Chinese Medicine (TCM). In this study, we used a multiple-session experiment to test whether electroacupuncture stimulation at two TCM vision-related acupoints, UB 60 and GB 37, located on the leg, could produce fMRI signal changes in the occipital regions of the brain, and the specificity of this effect when compared with stimulation at an adjacent non-acupoint (NAP). Six normal, acupuncture naïve subjects completed the study. Each subject participated in six identical scanning sessions. Voxelwise group analysis showed that electroacupuncture stimulation at both vision-related acupoints and the NAP produced modest, comparable fMRI signal decreases in the occipital cortex, including the bilateral cuneus, calcarine fissure and surrounding areas, lingual gyrus, and lateral occipital gyrus. Further analysis of fMRI signal changes in occipital cortex showed no significant difference among the three points, UB 60, GB 37, and NAP. Our results thus do not support the view that acupuncture stimulation at vision-related acupoints induces specific fMRI blood oxygen level dependent (BOLD) signal changes in the occipital cortex. We speculate that cross modal inhibition, produced by needling-evoked somatosensory stimulation, may account for our finding of BOLD signal decreases in the occipital cortex. Given the complexity of acupuncture systems and brain activity, additional work is required to determine whether functional neuroanatomical correlates of acupoint specificity can be validated by means of brain imaging tools.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1002/hbm.20481DOIArticle
http://www3.interscience.wiley.com/journal/116838594/abstractPublisherArticle
Additional Information:© 2007 Wiley-Liss, Inc. Received for publication 27 April 2007; Accepted 15 August 2007; Published online 7 November 2007. The authors would like to thank Dr. Kathleen Hui for her helpful suggestions and comments on the manuscript. Contract grant sponsor: NIH (NCCAM); Contract grant numbers: R21AT00949, PO1-AT002048, KO1AT003883, K24AT004095; Contract grant sponsor: NIH (NCRR); Contract grant number: P41RR14075,M01-RR-01066; Contract grant sponsor:MIND Institute.
Funders:
Funding AgencyGrant Number
NIHR21AT00949
NIHPO1-AT002048
NIHKO1AT003883
NIHK24AT004095
NIHP41RR14075
NIHM01-RR-01066
MIND InstituteUNSPECIFIED
Subject Keywords:acupuncture; electroacupuncture; vision-related acupoint; acupoint specificity; fMRI; brain imaging
Issue or Number:1
Record Number:CaltechAUTHORS:KONhbm09
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:KONhbm09
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:13604
Collection:CaltechAUTHORS
Deposited By: Jason Perez
Deposited On:13 May 2009 20:09
Last Modified:03 Oct 2019 00:41

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