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Competition and collaboration: GATA-3, PU.1, and Notch signaling in early T-cell fate determination

Rothenberg, Ellen V. and Scripture-Adams, Deirdre D. (2008) Competition and collaboration: GATA-3, PU.1, and Notch signaling in early T-cell fate determination. Seminars in Immunology, 20 (4). pp. 236-246. ISSN 1044-5323. PMCID PMC2634812. doi:10.1016/j.smim.2008.07.006.

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T-cell precursors remain developmentally plastic for multiple cell generations after entering the thymus, preserving access to developmental alternatives of macrophage, dendritic-cell, and even mast-cell fates. The underlying regulatory basis of this plasticity is that early T-cell differentiation depends on transcription factors which can also promote alternative developmental programs. Interfactor competition, together with environmental signals, keep these diversions under control. Here the pathways leading to several lineage alternatives for early pro-T-cells are reviewed, with close focus on the mechanisms of action of three vital factors, GATA-3, PU.1, and Notch-Delta signals, whose counterbalance appears to be essential for T-cell specification.

Item Type:Article
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URLURL TypeDescription CentralArticle
Rothenberg, Ellen V.0000-0002-3901-347X
Additional Information:© 2008 Elsevier Ltd. Available online 3 September 2008. We are most grateful to the primary authors of the work cited in this review, including members and former members of this laboratory whose results were discussed in detail. We especially thank Thomas Graf for patient encouragement and valuable insights, and Howard Petrie, Cornelis Murre, Hiroshi Kawamoto and Avinash Bhandoola for exciting discussions of work before publication. The authors’ work was supported by NIH grants CA90233, CA98925, and HL089123, the Albert Billings Ruddock Professorship, and the Louis A. Garfinkle Memorial Laboratory Fund.
Funding AgencyGrant Number
Albert Billings Ruddock ProfessorshipUNSPECIFIED
Louis A. Garfinkle Memorial Laboratory FundUNSPECIFIED
Subject Keywords:T-cell development; lineage commitment; mast cells; dendritic cells; transcription factor
Issue or Number:4
PubMed Central ID:PMC2634812
Record Number:CaltechAUTHORS:ROTsi08
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:13609
Deposited By: Tony Diaz
Deposited On:04 Mar 2009 00:47
Last Modified:08 Nov 2021 22:39

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