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Cortical cells should fire regularly, but do not

Softky, William R. and Koch, Christof (1992) Cortical cells should fire regularly, but do not. Neural Computation, 4 (5). pp. 643-646. ISSN 0899-7667. doi:10.1162/neco.1992.4.5.643.

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When a typical nerve cell is injected with enough current, it fires a regular stream of action potentials. But cortical cells in vivo usually fire irregularly, reflecting synaptic input from presynaptic cells as well as intrinsic biophysical properties. We have applied the theory of stochastic processes to spike trains recorded from cortical neurons (Tuckwell 1989) and find a fundamental contradiction between the large interspike variability observed and the much lower values predicted by well-accepted biophysical models of single cells.

Item Type:Article
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URLURL TypeDescription
Koch, Christof0000-0001-6482-8067
Additional Information:© 1992 Massachusetts Institute of Technology. Received 29 October 1991; accepted 4 February 1992. This research was funded by a NSF Presidential Young Investigator Award, by the Office of Naval Research, and by the James S. McDonnell Foundation.
Group:Koch Laboratory (KLAB)
Funding AgencyGrant Number
Office of Naval Research (ONR)UNSPECIFIED
James S. McDonnell FoundationUNSPECIFIED
Issue or Number:5
Record Number:CaltechAUTHORS:SOFnc92
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:13643
Deposited By: Tony Diaz
Deposited On:16 Jun 2009 19:29
Last Modified:26 Apr 2023 16:28

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