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Facilitating and nonfacilitating synapses on pyramidal cells: a correlation between physiology and morphology

Bower, James M. and Haberly, Lewis B. (1986) Facilitating and nonfacilitating synapses on pyramidal cells: a correlation between physiology and morphology. Proceedings of the National Academy of Sciences of the United States of America, 83 (4). pp. 1115-1119. ISSN 0027-8424. PMCID PMC323022. doi:10.1073/pnas.83.4.1115.

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Pyramidal cells in piriform cortex receive excitatory inputs from two different sources that are segregated onto adjacent segments of their apical dendrites. The present studies show that excitatory postsynaptic potentials (EPSPs) evoked by primary olfactory tract afferents that terminate on distal apical segments display paired shock facilitation whereas ESPSs evoked by intrinsic association fibers that terminate on proximal apical segments do not. An ultrastructural comparison of the presynaptic elements of these two fiber systems has revealed that the facilitating olfactory tract afferent synapses have a much lower packing density of synaptic vesicles than do the nonfacilitating association fiber synapses. Further, a search of the literature has revealed that where both morphological and physiological data are available for the same synapses, this same correlation appears to apply. We propose a hypothesis to account for this correlation based on synaptic vesicles to buffer internal calcium and the biochemical characteristics of preterminal calcium-dependent mechanisms affecting the number of vesicles available for release.

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Additional Information:© 1986 by the National Academy of Sciences. Communicated by Masakazu Konishi, September 19, 1985. We acknowledge the contribution of discussions with Mary Kennedy to the interpretation of our results. This work was supported by National Science Foundation Grant BNS 83118, National Institutes of Health Grant NS 19865, and a grant from the Graduate School Research Committee at the University of Wisconsin.
Funding AgencyGrant Number
NSFBNS 83118
NIHNS 19865
University of WisconsinUNSPECIFIED
Issue or Number:4
PubMed Central ID:PMC323022
Record Number:CaltechAUTHORS:BOWpnas86
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:13691
Deposited By: Tony Diaz
Deposited On:08 Jul 2009 17:29
Last Modified:08 Nov 2021 22:39

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