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NMDA-based pattern discrimination in a modeled cortical neuron

Mel, Bartlett W. (1992) NMDA-based pattern discrimination in a modeled cortical neuron. Neural Computation, 4 (4). pp. 502-517. ISSN 0899-7667. doi:10.1162/neco.1992.4.4.502.

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Compartmental simulations of an anatomically characterized cortical pyramidal cell were carried out to study the integrative behavior of a complex dendritic tree. Previous theoretical (Feldman and Ballard 1982; Durbin and Rumelhart 1989; Mel 1990; Mel and Koch 1990; Poggio and Girosi 1990) and compartmental modeling (Koch et al. 1983; Shepherd et al. 1985; Koch and Poggio 1987; Rall and Segev 1987; Shepherd and Brayton 1987; Shepherd et al. 1989; Brown et al. 1991) work had suggested that multiplicative interactions among groups of neighboring synapses could greatly enhance the processing power of a neuron relative to a unit with only a single global firing threshold. This issue was investigated here, with a particular focus on the role of voltage-dependent N-methyl-D-asparate (NMDA) channels in the generation of cell responses. First, it was found that when a large proportion of the excitatory synaptic input to dendritic spines is carried by NMDA channels, the pyramidal cell responds preferentially to spatially clustered, rather than random, distributions of activated synapses. Second, based on this mechanism, the NMDA-rich neuron is shown to be capable of solving a nonlinear pattern discrimination task. We propose that manipulation of the spatial ordering of afferent synaptic connections onto the dendritic arbor is a possible biological strategy for pattern information storage during learning.

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Additional Information:© 1992 Massachusetts Institute of Technology. Posted Online March 13, 2008. We are greatly indebted to Rodney Doulas and Kevan Martin for providing us with anatomical data from two cortical pyramidal cells, to John Moore and Michael Hines for their compartmental modeling program, NEURON, and to Tom Tromey for creating a 3-D graphical interface to NEURON. Thanks to Ojvind Bernander, Christof Koch, Ken Miller, Ernst Niebur, and Stephanie Me1 for useful discussions and many helpful comments on the manuscript. This work was supported by grants from the National Institutes of Mental Health, the Office of Naval Research, and the James S. McDonnell Foundation.
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National Institutes of Mental HealthUNSPECIFIED
Office of Naval ResearchUNSPECIFIED
James S. McDonnell FoundationUNSPECIFIED
Issue or Number:4
Record Number:CaltechAUTHORS:MELnc92
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:13758
Deposited By: Tony Diaz
Deposited On:25 Jun 2009 16:33
Last Modified:08 Nov 2021 22:40

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