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Response to comment on "Human-specific gain of function in a developmental enhancer"

Prabhakar, Shyam and Visel, Axel and Akiyama, Jennifer A. and Shoukry, Malak and Lewis, Keith D. and Holt, Amy and Plajzer-Frick, Ingrid and Morrison, Harris and FitzPatrick, David R. and Afzal, Veena and Pennacchio, Len A. and Rubin, Edward M. and Noonan, James P. (2009) Response to comment on "Human-specific gain of function in a developmental enhancer". Science, 323 (5915). 714d. ISSN 0036-8075.

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Duret and Galtier argue that human-specific sequence divergence and gain of function in the HACNS1 enhancer result from deleterious biased gene conversion (BGC) with no contribution from positive selection. We reinforce our previous conclusion by analyzing hypothesized BGC events genomewide and assessing the effect of recombination rates on human-accelerated conserved noncoding sequence ascertainment. We also provide evidence that AT → GC substitution bias can coexist with positive selection.

Item Type:Article
Related URLs:
URLURL TypeDescription
Visel, Axel0000-0002-4130-7784
Morrison, Harris0000-0001-8480-9787
Pennacchio, Len A.0000-0002-8748-3732
Additional Information:Copyright 2009 by the American Association for the Advancement of Science. 28 October 2008; accepted 12 January 2009.
Issue or Number:5915
Record Number:CaltechAUTHORS:PRAsci09
Persistent URL:
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:13778
Deposited By: Kristin Buxton
Deposited On:23 Mar 2009 22:47
Last Modified:09 Mar 2020 13:19

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