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Nanoparticle therapeutics: an emerging treatment modality for cancer

Davis, Mark E. and Chen, Zhou (Georgia) and Shin, Dong M. (2008) Nanoparticle therapeutics: an emerging treatment modality for cancer. Nature Reviews. Drug Discovery, 7 (9). pp. 771-782. ISSN 1474-1776. https://resolver.caltech.edu/CaltechAUTHORS:DAVnatrdd08

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Abstract

Nanoparticles — particles in the size range 1–100 nm — are emerging as a class of therapeutics for cancer. Early clinical results suggest that nanoparticle therapeutics can show enhanced efficacy, while simultaneously reducing side effects, owing to properties such as more targeted localization in tumours and active cellular uptake. Here, we highlight the features of nanoparticle therapeutics that distinguish them from previous anticancer therapies, and describe how these features provide the potential for therapeutic effects that are not achievable with other modalities. While large numbers of preclinical studies have been published, the emphasis here is placed on preclinical and clinical studies that are likely to affect clinical investigations and their implications for advancing the treatment of patients with cancer.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1038/nrd2614DOIArticle
https://rdcu.be/bXkzyPublisherFree ReadCube access
ORCID:
AuthorORCID
Davis, Mark E.0000-0001-8294-1477
Contact Email Address:mdavis@cheme.caltech.edu
Additional Information:© 2008 Nature Publishing Group. Published September 2008. This article is partially supported (Z.C. and D.M.S.) by a grant from the US National Cancer Institute, Center for Cancer Nanotechnology of Excellence (U54 CA119338).
Funders:
Funding AgencyGrant Number
NIHU54 CA119338
National Cancer InstituteUNSPECIFIED
Subject Keywords:PEGYLATED-LIPOSOMAL DOXORUBICIN; POLYMER-BOUND DOXORUBICIN; PACLITAXEL POLIGLUMEX XYOTAX; ADVANCED SOLID MALIGNANCIES; CONJUGATED L-ASPARAGINASE; PHASE-I; POLYETHYLENE-GLYCOL; BREAST-CANCER; MULTIDRUG-RESISTANCE; DRUG-DELIVERY
Issue or Number:9
Record Number:CaltechAUTHORS:DAVnatrdd08
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:DAVnatrdd08
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:13797
Collection:CaltechAUTHORS
Deposited By: Jason Perez
Deposited On:27 Mar 2009 21:26
Last Modified:21 Nov 2019 21:45

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