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Lesion mapping of cognitive abilities linked to intelligence

Gläscher, Jan and Tranel, Daniel and Paul, Lynn K. and Rudrauf, David and Rorden, Chris and Hornaday, Amanda and Grabowski, Thomas and Damasio, Hanna and Adolphs, Ralph (2009) Lesion mapping of cognitive abilities linked to intelligence. Neuron, 61 (5). pp. 681-691. ISSN 0896-6273. PMCID PMC2728583. http://resolver.caltech.edu/CaltechAUTHORS:20090410-093732463

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Abstract

The Wechsler Adult Intelligence Scale (WAIS) assesses a wide range of cognitive abilities and impairments. Factor analyses have documented four underlying indices that jointly comprise intelligence as assessed with the WAIS: verbal comprehension (VCI), perceptual organization (POI), working memory (WMI), and processing speed (PSI). We used nonparametric voxel-based lesion-symptom mapping in 241 patients with focal brain damage to investigate their neural underpinnings. Statistically significant lesion-deficit relationships were found in left inferior frontal cortex for VCI, in left frontal and parietal cortex for WMI, and in right parietal cortex for POI. There was no reliable single localization for PSI. Statistical power maps and cross-validation analyses quantified specificity and sensitivity of the index scores in predicting lesion locations. Our findings provide comprehensive lesion maps of intelligence factors, and make specific recommendations for interpretation and application of the WAIS to the study of intelligence in health and disease.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/j.neuron.2009.01.026DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2728583/PubMed CentralArticle
ORCID:
AuthorORCID
Paul, Lynn K.0000-0002-3128-8313
Adolphs, Ralph0000-0002-8053-9692
Additional Information:© 2009 Elsevier B.V. Accepted 29 January 2009. Published: March 11, 2009. Available online 11 March 2009. This work was supported in part by the Akademie der Naturforscher Leopoldina LPD Grant 9901/8-140 (J.G.); by grants from the National Institutes of Health: R01 NS054266 (C.R.), P01 NS19632 (D.T., H.D., and R.A.), and R01 DA022549 (D.T.); and by the Gordon and Betty Moore Foundation (R.A.). The authors declare no conflict of interest.
Funders:
Funding AgencyGrant Number
Akademie der Naturforscher Leopoldina9901/8-140
NIHR01 NS054266
NIHP01 NS19632
NIHR01 DA022549
Gordon and Betty Moore FoundationUNSPECIFIED
Subject Keywords:traumatic brain-injury; general intelligence; working-memory; WAIS-III; sex-differences; neural systems; speed; recognition; reliability; humans
Issue or Number:5
PubMed Central ID:PMC2728583
Record Number:CaltechAUTHORS:20090410-093732463
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20090410-093732463
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:13920
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:21 Apr 2009 18:50
Last Modified:13 Mar 2019 17:21

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