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The neural basis of Drosophila gravity-sensing and hearing

Kamikouchi, Azusa and Inagaki, Hidehiko K. and Effertz, Thomas and Hendrich, Oliver and Fiala, André and Göpfert, Martin C. and Ito, Kei (2009) The neural basis of Drosophila gravity-sensing and hearing. Nature, 458 (7235). pp. 165-172. ISSN 0028-0836. doi:10.1038/nature07810.

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The neural substrates that the fruitfly Drosophila uses to sense smell, taste and light share marked structural and functional similarities with ours, providing attractive models to dissect sensory stimulus processing. Here we focus on two of the remaining and less understood prime sensory modalities: graviception and hearing. We show that the fly has implemented both sensory modalities into a single system, Johnston's organ, which houses specialized clusters of mechanosensory neurons, each of which monitors specific movements of the antenna. Gravity- and sound-sensitive neurons differ in their response characteristics, and only the latter express the candidate mechanotransducer channel NompC. The two neural subsets also differ in their central projections, feeding into neural pathways that are reminiscent of the vestibular and auditory pathways in our brain. By establishing the Drosophila counterparts of these sensory systems, our findings provide the basis for a systematic functional and molecular dissection of how different mechanosensory stimuli are detected and processed.

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Additional Information:© 2009 Nature Publishing Group. Received 27 June 2008; Accepted 20 January 2009. We thank D. F. Eberl for JO15, C. J. O’Kane for UFWTRA19, B. J. Dickson for UAS-GFP S65T and eyFLP fly strains, H. Tanimoto for flies carrying tubulin-GAL80^ts and UAS-tetanus toxin, C. Kim for nan^dy5, M. J. Kernan for nan^36a, L. Liu for nompC-GAL4.25, A. Wong and G. Struhl for UAS>CD2, y>CD8::GFP, J. Urban and G. Technau for MZ-series enhancer trap strains, the members of the NP consortium (a group of eight laboratories in Japan that together produced a large collection of GAL4 lines) and D. Yamamoto for the NP-series strains, Bloomington Stock Centre for elav^c155-GAL4, D. F. Eberl and C. P. Kyriacou for courtship sound data, S. Fujita for 22C10 antibody, the Developmental Studies Hybridoma Bank for antibodies anti-Elav and nc82, T. Voller for help with calcium imaging, H. Otsuna and K. Shinomiya for preparing some figures, M. Dubbert, K. Ochsner, M. Matsukuma, S. Shuto and K. Yamashita for technical assistance, J. T. Albert, E. D. Hoopfer, B. Nadrowski, K. Endo, H. Otsuna, Y. Hiromi, E. Buchner and N. J. Strausfeld for discussion, and D. J. Anderson and S. Yorozu for sharing unpublished data. This work was supported by the Japanese Cell Science Research Foundation, the Alexander von Humboldt Foundation, and the Japan Society for the Promotion of Science (to A.K.), the DFG Collaborative Research Centre 554 (to A.F.), the Volkswagen Foundation, the BMBF Bernstein Network for Computational Neuroscience, and the DFG Research Centre Molecular Physiology of the Brain (to M.C.G.), and the Human Frontier Science Program Organisation, BIRD/Japan Science and Technology Agency, and the Japan Society for the Promotion of Science (to K.I.).
Funding AgencyGrant Number
Japanese Cell Science Research FoundationUNSPECIFIED
Alexander von Humboldt FoundationUNSPECIFIED
Japan Society for the Promotion of ScienceUNSPECIFIED
DFG Collaborative Research Centre 554UNSPECIFIED
Volkswagen FoundationUNSPECIFIED
BMBF Bernstein Network for Computational NeuroscienceUNSPECIFIED
DFG Research Centre Molecular Physiology of the BrainUNSPECIFIED
Human Frontier Science Program OrganisationUNSPECIFIED
BIRD/Japan Science and Technology AgencyUNSPECIFIED
Issue or Number:7235
Record Number:CaltechAUTHORS:20090414-082235712
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:13962
Deposited By: Tony Diaz
Deposited On:30 Apr 2009 18:09
Last Modified:08 Nov 2021 22:42

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