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Comprehensive spatiotemporal analysis of early chick neural crest network genes

Khudyakov, Jane and Bronner-Fraser, Marianne (2009) Comprehensive spatiotemporal analysis of early chick neural crest network genes. Developmental Dynamics, 238 (3). pp. 716-723. ISSN 1058-8388. PMCID PMC2650819. doi:10.1002/dvdy.21881.

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Specification of neural crest progenitors begins during gastrulation at the neural plate border, long before migration or differentiation. Neural crest cell fate is acquired by progressive activation of discrete groups of transcription factors that appear to be highly conserved in vertebrates; however, comprehensive analysis of their expression has been lacking in chick, an important model system for neural crest development. To address this, we analyzed expression of 10 transcription factors that are known specifiers of neural plate border and neural crest fate and compared them across developmental stages from gastrulation to neural crest migration. Surprisingly, we find that most neural crest specifiers are expressed during gastrulation in chick, concomitant with and in similar domains as neural plate border specifiers. This finding suggests that interactions between these molecules may occur much earlier than previously thought, an important consideration for interpretation of functional studies.

Item Type:Article
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URLURL TypeDescription CentralArticle
Bronner-Fraser, Marianne0000-0003-4274-1862
Additional Information:© 2009 Wiley-Liss, Inc. Accepted 24 December 2008. We thank Tatjana Sauka-Spengler, Sujata Bhattacharyya, Meyer Barembaum, and Jack Sechrist for their technical advice and discussion. M.B.-F. was funded by the NIH.
Funding AgencyGrant Number
Subject Keywords:chick neural crest; neural plate border; gene regulatory network; NC-GRN
Issue or Number:3
PubMed Central ID:PMC2650819
Record Number:CaltechAUTHORS:20090414-091753664
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:13965
Deposited By: Tony Diaz
Deposited On:14 Apr 2009 20:54
Last Modified:08 Nov 2021 22:42

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