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Stability of carbohydrate-modified vesicles in vivo: Comparative effects of ceramide and cholesterol glycoconjugates

Wu, Po-Shun and Wu, Hsiu-Mei and Tin, George W. and Schuh, Joseph R. and Croasmun, William R. and Baldeschwieler, John D. and Shen, T. Y. and Ponpipom, M. M. (1982) Stability of carbohydrate-modified vesicles in vivo: Comparative effects of ceramide and cholesterol glycoconjugates. Proceedings of the National Academy of Sciences of the United States of America, 79 (18). pp. 5490-5493. ISSN 0027-8424.

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The stability and tissue distribution of lipid vesicles modified at the surface by the incorporation of either a galactosyl ceramide (GalCer) or a galactosyl cholesterol (GalChol) glycoconjugate have been studied in mice by measuring the release of vesicle-entrapped (111)In. Although the tissue distributions of both vesicle types were similar, the GalCer-containing vesicles were markedly less stable than those prepared with GalChol, whether administered orally or by intraperitoneal injection. Physical characterization of the vesicles in vitro suggests that the increased disruption rate for GalCer vesicles in vivo is related to structural instabilities induced by the cerebroside, which can then result in either an increased rate of vesicle uptake by tissues or a greater susceptibility to lysis. These studies demonstrate the importance of the nonpolar anchoring groups in determining the fate of surface-modified vesicles in vivo.

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Additional Information:Copyright © 1982 by the National Academy of Sciences. Contributed by John D. Baldeschwieler, June 7, 1982. The NMR spectra were obtained at the Southern California Regional NMR Facility, California Institute of Technology, Pasadena, CA. This research was supported by grants from the National Science Foundation (CHE79-19401) and the National Institutes of Health (GM21111-09) and a grant from Merck and Co., Inc. The publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U. S. C. §1734 solely to indicate this fact.
Subject Keywords:liposome, perturbed angular correlation spectroscopy, NMR, drug delivery system
Issue or Number:18
Record Number:CaltechAUTHORS:WUPpnas82
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:1424
Deposited By: Tony Diaz
Deposited On:18 Jan 2006
Last Modified:02 Oct 2019 22:43

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