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Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease

Acloque, Hervé and Adams, Meghan S. and Fishwick, Katherine and Nieto, M. Angela and Bronner-Fraser, Marianne (2009) Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease. Journal of Clinical Investigation, 119 (6). pp. 1438-1449. ISSN 0021-9738. PMCID PMC2689100. https://resolver.caltech.edu/CaltechAUTHORS:20090709-100213332

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Abstract

The events that convert adherent epithelial cells into individual migratory cells that can invade the extracellular matrix are known collectively as epithelial-mesenchymal transition (EMT). Throughout evolution, the capacity of cells to switch between these two cellular states has been fundamental in the generation of complex body patterns. Here, we review the EMT events that build the embryo and further discuss two prototypical processes governed by EMT in amniotes: gastrulation and neural crest formation. Cells undergo EMT to migrate and colonize distant territories. Not surprisingly, this is also the mechanism used by cancer cells to disperse throughout the body.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1172/JCI38019DOIArticle
http://www.jci.org/articles/view/38019PublisherArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2689100/PubMed CentralArticle
ORCID:
AuthorORCID
Bronner-Fraser, Marianne0000-0003-4274-1862
Additional Information:© 2009 American Society for Clinical Investigation. Published June 1, 2009. The work in our laboratories is supported by grants from the Spanish Ministry of Science and Innovation (grants BFU2005-05772, BFU2008-01042, NAN2004-09230-C04-04, CONSOLIDER-INGENIO 2010 CSD2007-00017 and CSD2007-00023) and the Generalitat Valenciana (Prometeo/2008/049) to M.A. Nieto; and by NIH grants R01 DE017911 and P50HG004071 to M. Bronner-Fraser. H. Acloque was supported by the I3P Programme (European Social Fund/MEC) and M.S. Adams by the Morgan fellowship from the Gordon and Betty Moore Foundation.
Funders:
Funding AgencyGrant Number
Ministerio de Ciencia e Innovación (MCINN)BFU2005-05772
Ministerio de Ciencia e Innovación (MCINN)BFU2008-01042
Ministerio de Ciencia e Innovación (MCINN)NAN2004-09230-C04-04
Ministerio de Ciencia e Innovación (MCINN)CONSOLIDER-INGENIO 2010 CSD2007-00017
Ministerio de Ciencia e Innovación (MCINN)CSD2007-00023
Generalitat ValencianaPrometeo/2008/049
NIHR01 DE017911
NIHP50HG004071
I3P Programme (European Social Fund/MEC)UNSPECIFIED
Gordon and Betty Moore FoundationUNSPECIFIED
Issue or Number:6
PubMed Central ID:PMC2689100
Record Number:CaltechAUTHORS:20090709-100213332
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20090709-100213332
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:14540
Collection:CaltechAUTHORS
Deposited By: Jason Perez
Deposited On:28 Jul 2009 20:49
Last Modified:03 Oct 2019 00:50

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