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Computational models of heart pumping efficiencies based on contraction waves in spiral elastic bands

Grosberg, Anna and Gharib, Morteza (2009) Computational models of heart pumping efficiencies based on contraction waves in spiral elastic bands. Journal of Theoretical Biology, 257 (3). pp. 359-370. ISSN 0022-5193. http://resolver.caltech.edu/CaltechAUTHORS:20090714-105421355

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Abstract

We present a framework for modeling biological pumping organs based on coupled spiral elastic band geometries and active wave-propagating excitation mechanisms. Two pumping mechanisms are considered in detail by way of example: one of a simple tube, which represents a embryonic fish heart and another more complicated structure with the potential to model the adult human heart. Through finite element modeling different elastic contractions are induced in the band. For each version the pumping efficiency is measured and the dynamics are evaluated. We show that by combining helical shapes of muscle bands with a contraction wave it is possible not only to achieve efficient pumping, but also to create desired dynamics of the structure. As a result we match the function of the model pumps and their dynamics to physiological observations.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/j.jtbi.2008.11.022DOIUNSPECIFIED
Additional Information:© 2008 Elsevier. Received 29 February 2008; revised 18 August 2008; accepted 19 November 2008. Available online 6 December 2008. Supplementary data associated with this article can be found in the online version at doi:10.1016/j.jtbi.2008.11.022.
Group:GALCIT
Subject Keywords:Cardiac modeling; Left ventricular twist; Myocardium macro-structure; Finite element simulations
Issue or Number:3
Record Number:CaltechAUTHORS:20090714-105421355
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20090714-105421355
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:14587
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:11 Aug 2009 16:55
Last Modified:30 Sep 2016 17:35

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