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Prion topology and toxicity

Aguzzi, Adriano and Steele, Andrew D. (2009) Prion topology and toxicity. Cell, 137 (6). pp. 994-996. ISSN 0092-8674.

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Inactivation of mahogunin, an E3 ubiquitin ligase, causes a spongiform encephalopathy resembling prion disease. Chakrabarti and Hegde (2009) now report that prion proteins with aberrant topologies inactivate mahogunin, providing a plausible explanation for certain aspects of prion pathology.

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Additional Information:©2009 Elsevier Inc. A.A. is supported by the Swiss National Foundation, European Union FP7, and the Stammbach Foundation. A.D.S. is supported by the Broad Fellows in Brain Circuitry program at Caltech.
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Swiss National FoundationUNSPECIFIED
Stammbach FoundationUNSPECIFIED
Broad Fellows in Brain Circuitry program at CaltechUNSPECIFIED
Issue or Number:6
Record Number:CaltechAUTHORS:20090729-092723886
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:14715
Deposited By: Ruth Sustaita
Deposited On:07 Aug 2009 20:59
Last Modified:03 Oct 2019 00:52

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