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Prion topology and toxicity

Aguzzi, Adriano and Steele, Andrew D. (2009) Prion topology and toxicity. Cell, 137 (6). pp. 994-996. ISSN 0092-8674. https://resolver.caltech.edu/CaltechAUTHORS:20090729-092723886

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Abstract

Inactivation of mahogunin, an E3 ubiquitin ligase, causes a spongiform encephalopathy resembling prion disease. Chakrabarti and Hegde (2009) now report that prion proteins with aberrant topologies inactivate mahogunin, providing a plausible explanation for certain aspects of prion pathology.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/j.cell.2009.05.041DOIUNSPECIFIED
Additional Information:©2009 Elsevier Inc. A.A. is supported by the Swiss National Foundation, European Union FP7, and the Stammbach Foundation. A.D.S. is supported by the Broad Fellows in Brain Circuitry program at Caltech.
Funders:
Funding AgencyGrant Number
Swiss National FoundationUNSPECIFIED
European Union FP7UNSPECIFIED
Stammbach FoundationUNSPECIFIED
Broad Fellows in Brain Circuitry program at CaltechUNSPECIFIED
Issue or Number:6
Record Number:CaltechAUTHORS:20090729-092723886
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20090729-092723886
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:14715
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:07 Aug 2009 20:59
Last Modified:03 Oct 2019 00:52

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